DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes

Објеката

Тип
Рад у часопису
Верзија рада
објављена верзија
Језик
енглески
Креатор
Aleksandar Mijatović, Angelina Caković, Aleksandar Lolić, Snezana Sretenović, Marko Živanović, Dragana Seklić, Jovana Bogojeski, Biljana Petrović
Извор
Journal of the Serbian Chemical Society
Датум издавања
2023
Сажетак
Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV-Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1-3 also showed a possibility for DNA intercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity.
Број
-
doi
10.2298/JSC230614063M
issn
0352-5139
Subject
General Chemistry
Шира категорија рада
M20
Ужа категорија рада
М23
Права
Затворени приступ
Лиценца
Creative Commons – Attribution-No Derivative Works 4.0 International
Формат
.pdf

Aleksandar Mijatović, Angelina Caković, Aleksandar Lolić, Snezana Sretenović, Marko Živanović, Dragana Seklić, Jovana Bogojeski, Biljana Petrović. "DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes" in Journal of the Serbian Chemical Society (2023). https://doi.org/10.2298/JSC230614063M

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