326 items

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  Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach cite

  Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)

  Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...

  pyrazoloquinolinones, nanocrystals, wet media milling, fasted/fed bioavailability

  Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188

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  Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study cite

  Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)

  Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...

  Pharmaceutical Science

  Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557

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  Regional Slope Stability Analysis in Landslide Hazard Assessment Context, North Macedonia Example cite

  Miloš Marjanović, Biljana Abolmasov, Igor Peshevski, James Reeves, Irena Georgievska (2020)

  Miloš Marjanović, Biljana Abolmasov, Igor Peshevski, James Reeves, Irena Georgievska. "Regional Slope Stability Analysis in Landslide Hazard Assessment Context, North Macedonia Example" in Understanding and Reducing Landslide Disaster Risk, Springer International Publishing (2020). https://doi.org/10.1007/978-3-030-60227-7_29

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  Iron (III) Oxide Fabrication From Natural Clay With Reference to Phase Transformation γ- → α- Fe2O3 cite

  Šaponjić A., Šaponjić Đ., Nikolić V., Milošević M., Marinović-Cincović M., Gyoshev S., Vuković M., Kokunešoski M. (2017)

  Šaponjić A., Šaponjić Đ., Nikolić V., Milošević M., Marinović-Cincović M., Gyoshev S., Vuković M., Kokunešoski M.. "Iron (III) Oxide Fabrication From Natural Clay With Reference to Phase Transformation γ- → α- Fe2O3" in Science of Sintering 49 no. 2, Srbija:Serbian Academy of Sciences and Arts (2017): 197-205. https://doi.org/https://doi.org/10.2298/SOS170

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  Microscopical characterization of carbon materials derived from coal and petroleum and their interaction phenomena on making steel electrodes, anodes and cathodes blocks cite

  Predeanu G., Panaitescu C., Balanescu M., Bieg G., Gómez Borrego A., Diez M.A., Kwiecińska B., Marques M., Mastalerz M., Misz-Kennan M., Pusz S., Suárez Ruiz I., Rodriguez S., Singh A.K., Varma A., Zdravkov A., Životić Dragana (2013)

  Predeanu G., Panaitescu C., Balanescu M., Bieg G., Gómez Borrego A., Diez M.A., Kwiecińska B., Marques M., Mastalerz M., Misz-Kennan M., Pusz S., Suárez Ruiz I., Rodriguez S., Singh A.K., Varma A., Zdravkov A., Životić Dragana. "Microscopical characterization of carbon materials derived from coal and petroleum and their interaction phenomena on making steel electrodes, anodes and cathodes blocks" in 64rd Annual Meeting of the International Committee for Coal and Organic Petrology (ICCP) Book of Abstracts, Sosnowiec, Poland:University of Silesia, Sosnowiec (2013): 108-109

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  The Dinaride Ophiolite Belt – derived olistostrome melange at the northen slope of Moračka Kapa (Montenegro): evidence of the emplacement of the southeast Bosnian-Durmitor terrane cite

  Karamata Stevan, Dimitrijević Mara, Dimitrijević Milorad, Ercegovac Marko, Kalezić M., Milovanović Dragan, Mirković M., Olujić Jovan, Popvić A., Pajović M., Radosinović M., Stijović V., Sudar Milan, Cvetković Vladica, Šarić Kristina, Zakaridze G. (2010)

  Karamata Stevan, Dimitrijević Mara, Dimitrijević Milorad, Ercegovac Marko, Kalezić M., Milovanović Dragan, Mirković M., Olujić Jovan, Popvić A., Pajović M., Radosinović M., Stijović V., Sudar Milan, Cvetković Vladica, Šarić Kristina, Zakaridze G.. "The Dinaride Ophiolite Belt – derived olistostrome melange at the northen slope of Moračka Kapa (Montenegro): evidence of the emplacement of the southeast Bosnian-Durmitor terrane" in Bulletin Classe des sciences mathématiques et natturalles - Sciences natturalles 140 no. 46, Beograd:Srpska akademija nauka i umetnosti (2010): 29-40

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  Microscopical characterization of carbon materials derived from coal and petroleum and their interaction phenomena in making steel electrodes, anodes and cathode blocks for the microscopy of carbon materials working group of the ICCP cite

  Predeanu G., Panaitescu C., Bălănescu M., Bieg G., Gómez Borrego A., Diez M.A., Hackley P., Kwiecińska B., Marques M., Mastalerz M., Misz-Kennan M., Pusz S., Suárez Ruiz I., Rodrigues S., Singh A.K., Varma A.K., Zdravkov A., Životić Dragana (2015)

  Predeanu G., Panaitescu C., Bălănescu M., Bieg G., Gómez Borrego A., Diez M.A., Hackley P., Kwiecińska B., Marques M., Mastalerz M., Misz-Kennan M., Pusz S., Suárez Ruiz I., Rodrigues S., Singh A.K., Varma A.K., Zdravkov A., Životić Dragana. "Microscopical characterization of carbon materials derived from coal and petroleum and their interaction phenomena in making steel electrodes, anodes and cathode blocks for the microscopy of carbon materials working group of the ICCP" in International Journal of Coal Geology 139, Amsterdam, Netherlands:Elsevier BV (2015): 63-79. https://doi.org/10.1016/j.coal.2014.07.011

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  Foreign molecules and ions in beryl obtained by infrared and visible spectroscopy cite

  Jelić I., Logar M., Milošević M. (2017)

  Jelić I., Logar M., Milošević M.. "Foreign molecules and ions in beryl obtained by infrared and visible spectroscopy" in Geophysical Research Abstracts Geophysical Research Abstracts 19, Vienna, Austria:Copernicus Publications (2017): 2479

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  Istraživanje faune makrozoobentosa u izvorima cite

  K. Belanović, I. Živić, Z. Marković, Ilić Marija, M. Radulović, M. Živić (2010)

  K. Belanović, I. Živić, Z. Marković, Ilić Marija, M. Radulović, M. Živić. "Istraživanje faune makrozoobentosa u izvorima" in Rizici i eko -bezbednost u postmodernom ambijentu -Internacionalna konferencija, septembar 19-12 jun, Novi Pazar, Novi Pazar:Državni univerzitet u Novom Pazaru (DUNP) (2010): 89-97

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  A contribution to Jovan Cvijićs consideration of the Visočica river source cite

  Nikić Zoran, Dokmanović Petar, Anđelić M, Lekić M (2015)

  Nikić Zoran, Dokmanović Petar, Anđelić M, Lekić M. "A contribution to Jovan Cvijićs consideration of the Visočica river source" in Book of Abstracts of International Scientific Conference 150th ANNIVERSARY OF JOVAN CVIJIĆS BIRTH, Beograd:Serbian Academy of Sciences and Arts, Geographical institute “Jovan Cvijić” (2015)

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  Mineralogy and thermal properties of clay from Slatina (Ub, Serbia) cite

  Milošević M., Logar M., Kaluđerović L., Jelić I. (2017)

  Milošević M., Logar M., Kaluđerović L., Jelić I.. "Mineralogy and thermal properties of clay from Slatina (Ub, Serbia)" in Geophysical Research Abstracts Geophysical Research Abstracts 19, Vienna, Austria:Copernicus Publications (2017): 2044

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  Mandible shape differentiation between Mammuthus trogontherii and M. primigenius and mandible shape ontogeny in M. primigenius specimens from Serbia: A preliminary explorative geometric morphometric study cite

  Paunović Gordana, Bogićević Katarina, Urošević Aleksandar (2017)

  Paunović Gordana, Bogićević Katarina, Urošević Aleksandar. "Mandible shape differentiation between Mammuthus trogontherii and M. primigenius and mandible shape ontogeny in M. primigenius specimens from Serbia: A preliminary explorative geometric morphometric study" in Quaternary International no. 443 (A) (2017): 212-220. https://doi.org/https://doi.org/10.1016/j.quai

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  The Early Middle Palaeolithic in the Balkans. The case of Velika and Mala Balanica (Serbia) cite

  Mihailović, D., Belen Marín-Arroyo, A., Bogićević Katarina, Morley, M. & Roksandić, M. (2011)

  Mihailović, D., Belen Marín-Arroyo, A., Bogićević Katarina, Morley, M. & Roksandić, M.. "The Early Middle Palaeolithic in the Balkans. The case of Velika and Mala Balanica (Serbia)" in European Society for the Study of Human Evolution (ESHE). Inaugural Meeting, 23-24. September, Leipzig, Germany. (2011): 71-71

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  Properties and characterization of a clay raw material from Miličinica (Serbia) for use in the ceramic industry cite

  Milošević M., Logar M. (2017)

  Milošević M., Logar M.. "Properties and characterization of a clay raw material from Miličinica (Serbia) for use in the ceramic industry" in Clay Minerals 52 no. 3, UK:The Mineralogical Society (2017): 329-340. https://doi.org/https://doi.org/10.1180/claymi

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  The Late Cretaceous Klepa basalts in Macedonia (FYROM) - Constraints on the final stage of Tethys closure in the Balkans cite

  Dejan Prelević, S. Wehrheim, M. Reutter, Romer, R.L., Blažo Boev, Milica Božović, P. van den Bogaard, Vladica Cvetković, Stefan M. Schmid (2017)

  Dejan Prelević, S. Wehrheim, M. Reutter, Romer, R.L., Blažo Boev, Milica Božović, P. van den Bogaard, Vladica Cvetković, Stefan M. Schmid. "The Late Cretaceous Klepa basalts in Macedonia (FYROM) - Constraints on the final stage of Tethys closure in the Balkans" in Émile Argand Conference - 13th Workshop on Alpine Geological Studies - September 7th-18th 2017 in Serbia, Zlatibor Mts., Beograd:University of Belgrade - Faculty of Mining and Geology (2017): 87-87

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  Characterization of clays from Slatina (Ub, Serbia) for potential uses in the ceramic industry cite

  Milošević M., Logar M., Kaluđerović L., Jelić I. (2017)

  Milošević M., Logar M., Kaluđerović L., Jelić I.. "Characterization of clays from Slatina (Ub, Serbia) for potential uses in the ceramic industry" in Energy Procedia Energy Procedia 125, :Elsevier (2017): 650-655. https://doi.org/10.1016/j.egypro.2017.08.270

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  Analiza stabilnosti kosine na magistralnom putu M-1, deonica Lipci-Ljuta cite

  Ksenija Gredić (2024)

  Katedra za Geotehniku održala je sednicu na kojoj mi je odobrena tema za završnirad pod naslovom “Analiza stabilnosti kosine na magistralnom putu M-1, deonica Lipci-Ljuta” u opštini Kotor.Za mentora je izabran van.prof.Miloš Marjanović, dok za članove komisije su izabrani prof.dr. Biljana Abolmasov i doc.dr. Zoran Berisavljević. Tokom izrade završnog rada, korišćeni su podaci iz “Elaborata o rekonstrukciji magistralnog puta M-1 (M-2), dionica Lipci-Ljuta, dužine cca 15km”, kao i ostala odgovarajuća stručna literatura. Na osnovu terenskih radova i dobijenih rezultata ...

  analiza stabilnosti, stijenska masa, kinematska analiza, inženjerskogeološko kartiranje

  Ksenija Gredić. Analiza stabilnosti kosine na magistralnom putu M-1, deonica Lipci-Ljuta, 2024

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  Analiza stabilnosti kosine na magistralnom putu M-1, deonica Lipci-Ljuta cite

  Ksenija Gredić (2024)

  Katedra za Geotehniku održala je sednicu na kojoj mi je odobrena tema za završnirad pod naslovom “Analiza stabilnosti kosine na magistralnom putu M-1, deonica Lipci-Ljuta” u opštini Kotor.Za mentora je izabran van.prof.Miloš Marjanović, dok za članove komisije su izabrani prof.dr. Biljana Abolmasov i doc.dr. Zoran Berisavljević. Tokom izrade završnog rada, korišćeni su podaci iz “Elaborata o rekonstrukciji magistralnog puta M-1 (M-2), dionica Lipci-Ljuta, dužine cca 15km”, kao i ostala odgovarajuća stručna literatura. Na osnovu terenskih radova i dobijenih rezultata ...

  analiza stabilnosti, stijenska masa, kinematska analiza, inženjerskogeološko kartiranje

  Ksenija Gredić. Analiza stabilnosti kosine na magistralnom putu M-1, deonica Lipci-Ljuta, 2024

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  Identification of alginite and bituminite in rocks other than coal: results of Round Robin Exercises of the Identification of Dispersed Organic Matter Working Group of the ICCP cite

  Kus J., Araujo C.V., Borrego A.G., Flores D., Hackley P.C., Hámor-Vidó M., Kalaitzidis S., Kommeren C.J., Kwiecińska B., Mastalerz M., Mendonça Filho J.G., Menezes T.R., Misz-Kennan M., Nowak G.J., Petersen H.I., Rallakis D., Suárez-Ruiz I., Sýkorová I., Životić Dragana (2017)

  Kus J., Araujo C.V., Borrego A.G., Flores D., Hackley P.C., Hámor-Vidó M., Kalaitzidis S., Kommeren C.J., Kwiecińska B., Mastalerz M., Mendonça Filho J.G., Menezes T.R., Misz-Kennan M., Nowak G.J., Petersen H.I., Rallakis D., Suárez-Ruiz I., Sýkorová I., Životić Dragana. "Identification of alginite and bituminite in rocks other than coal: results of Round Robin Exercises of the Identification of Dispersed Organic Matter Working Group of the ICCP" in International Journal of Coal Geology 178, Amsterdam, Netherlands:Elsevier BV (2017): 26-38. https://doi.org/10.1016/j.coal.2017.04.013

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  Fe doped TiO2 prepared by microwave-assisted hydrothermal process for removal of As(III) and As(V) from water cite

  Anđelković Ivan B, Stanković Dalibor M, Nešić Jelena, Krstić Jugoslav B, Vulić Predrag, Manojlović Dragan D, Roglić Goran M (2014)

  Anđelković Ivan B, Stanković Dalibor M, Nešić Jelena, Krstić Jugoslav B, Vulić Predrag, Manojlović Dragan D, Roglić Goran M. "Fe doped TiO2 prepared by microwave-assisted hydrothermal process for removal of As(III) and As(V) from water" in Industrial and Engineering Chemistry Research 53 no. 27, Washington:American Chemical Society (2014): 10841-10848. https://doi.org/10.1021/ie500849r