133 items

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  Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach cite

  Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)

  Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...

  pyrazoloquinolinones, nanocrystals, wet media milling, fasted/fed bioavailability

  Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188

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  Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study cite

  Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)

  Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...

  Pharmaceutical Science

  Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557

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  Model za optimizaciju graničnog saržaja metala u rudi u funkciji dugoročnog planiranja površinskih kopova cite

  Daniel P. KRŽANOVIĆ (2016)

  površinski kop, dugoročno planiranje, optimizacija graničnog sadržaja

  Daniel P. KRŽANOVIĆ. Model za optimizaciju graničnog saržaja metala u rudi u funkciji dugoročnog planiranja površinskih kopova, Beograd:Rudarsko Geološki Fakultet, 2016

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  Model za optimizaciju graničnog saržaja metala u rudi u funkciji dugoročnog planiranja površinskih kopova cite

  Daniel P. Kržanović (2016-06-14)

  Optimizacija graničnog sadržaja metala u rudi jedan je od osnovnih koraka u planiranju i dizajniranju površinskih kopova i ima za cilj postizanje maksimalne neto sadašnje vrednosti (NPV). Iz tog razloga, optimizacija graničnog sadržaja i danas je predmet mnogih istraživanja u rudarskoj nauci, sa ciljem rešavanja praktičnih problema u eksploataciji ležišta.Dugoročno planiranje eksploatacije na površinskim kopovima podrazumeva sagledavanje svih relevantih parametara i faktora (geologije rudnog ležišta, tehnologije proizvodnog procesa, kapaciteta otkopavanja i prerade, troškova, cena metala, iskorišćenja i dr) kako ...

  površinski kop, dugoročno planiranje, optimizacija graničnog sadržaja, maksimizacija neto sadašnje vrednosti (NPV).

  Daniel P. Kržanović. "Model za optimizaciju graničnog saržaja metala u rudi u funkciji dugoročnog planiranja površinskih kopova" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2016-06-14)

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  E-Waste Management in Serbia, Focusing on the Possibility of Applying Automated Separation Using Robots cite

  Dragana Nišić, Branko Lukić, Zaviša Gordić, Uroš Pantelić, Arso Vukićević (2024)

  reciklaža, e-otpad, robot, separacija otpada, cirkularna ekonomija

  Dragana Nišić, Branko Lukić, Zaviša Gordić, Uroš Pantelić, Arso Vukićević. "E-Waste Management in Serbia, Focusing on the Possibility of Applying Automated Separation Using Robots" in Applied Sciences, MDPI AG (2024). https://doi.org/10.3390/app14135685

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  E-Connecting Balkan Languages cite

  Cvetana Krstev, Ranka Stanković, Duško Vitas, Svetla Koeva (2009)

  In this paper we present a versatile language processing tool that can be successfully used for many Balkan languages. This tool relies for its work on several sophisticated textual and lexical resources that were developed for most of Balkan languages. These resources are based on several de facto standards in natural language processing.

  Query expansion, e-dictionary, wordnet, proper name, aligned text

  Cvetana Krstev, Ranka Stanković, Duško Vitas, Svetla Koeva. "E-Connecting Balkan Languages" in Proceedings of the Workshop Workshop on Multilingual resources, technologies and evaluation for Central and Eastern European Languages, 17 September 2009, eds. C. Vertan, S. Piperidis, E. Paskaleva and Milena Slavcheva, Borovets, Bulgaria : Association for Computational Linguistics Stroudsburg, PA, USA (2009)

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  Dasht-e-kain porphyry copper prospect in context of the metalogeny of chagai calcalkaline volcano-intrusive complexs chagai district(baluchistan) Pakistan cite

  Mahmood Ahmad (1986)

  Copper, metalogeny, Pakistan

  Mahmood Ahmad. Dasht-e-kain porphyry copper prospect in context of the metalogeny of chagai calcalkaline volcano-intrusive complexs chagai district(baluchistan) Pakistan, Beograd:Rudarsko Geološki Fakultet, 1986

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  Building Terminological Resources in an e-Learning Environment cite

  Ranka Stanković, Ivan Obradović, Olivera Kitanović, Ljiljana Kolonja (2012)

  Ranka Stanković, Ivan Obradović, Olivera Kitanović, Ljiljana Kolonja. "Building Terminological Resources in an e-Learning Environment" in Proceedings of the Third International Conference on e-Learning, eLearning-2012, September 2012, Belgrade, Serbia, Belgrade : Belgrade Metropolitan University (2012)

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  Formative evaluation of e-learning projects with the logical framework approach cite

  Roberto Linzalone, Giovani Schiuma, Ivan Obradović, Ranka Stanković (2015)

  Roberto Linzalone, Giovani Schiuma, Ivan Obradović, Ranka Stanković. "Formative evaluation of e-learning projects with the logical framework approach" in The Sixth International Conference on e-Learning (eLearning-2015), September 2015, Belgrade, Serbia, Belgrade Metropolitan Univesity (2015)

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  A Conceptual hydrogeological model for the open pit mine „Polje E“ (Kolubara coal basin, Serbia) cite

  Bajić Dragoljub, Polomčić Dušan (2012)

  Bajić Dragoljub, Polomčić Dušan. "A Conceptual hydrogeological model for the open pit mine „Polje E“ (Kolubara coal basin, Serbia)" in Proceedings of 9th Symposium GIS Ostrava 2012 - Surface models for geosciences,, Ostrava: (2012): 1-12

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  3D Hydrodinamic model of open pit mine “Polje E” (Kolubara coal basin) cite

  Polomčić Dušan, Bajić Dragoljub (2011)

  Polomčić Dušan, Bajić Dragoljub. "3D Hydrodinamic model of open pit mine “Polje E” (Kolubara coal basin)" in Proceedings of the V International Conference “Coal 2011”, Zlatibor, Serbia, 19-22 October, 2011, Belgrade:Yugoslav Opencast Mining Committee (2011): 320-330

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  Abandoned chrysotile asbestos mines in Serbia: An environmental mineralogical study cite

  Hargitai Anna, Tóth E., Vasković Nada, Milošević Maja, Weiszburg T.G. (2012)

  Hargitai Anna, Tóth E., Vasković Nada, Milošević Maja, Weiszburg T.G.. "Abandoned chrysotile asbestos mines in Serbia: An environmental mineralogical study" in Acta Mineralogica-Petrographica, Abstract Series 7, Szeged, Hungary:University of Szeged (2012): 53-53

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  Analysis of the SCI, SCI-E and SSCI Journals in the Fields of Mining Transport, Haulage and Hoisting. cite

  Ristović Ivica, Dašić Predrag, Dašić Jovan (2014)

  Ristović Ivica, Dašić Predrag, Dašić Jovan. "Analysis of the SCI, SCI-E and SSCI Journals in the Fields of Mining Transport, Haulage and Hoisting." in Applied Mechanics and Materials no. 683, Podbanske, Slovakia:Trans Tech Publications, Switzerland (2014): 78-85. https://doi.org/10.4028/www.scientific.net/AMM

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  Geologicac Features and 3D Model of the Field „E“, Kolubara Basin cite

  Veličković Marija, Životić Dragana (2011)

  Veličković Marija, Životić Dragana. "Geologicac Features and 3D Model of the Field „E“, Kolubara Basin" in The Geology in Digital Age - Proceedings of the 17th Meeting of the Association of European Geological Societies, MAEGS 17, Belgrade, [14-18. 09.] 2011., Belgrade:Serbian Geological Society (2011): 143-147

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  Maximizing the net present value by applying an optimal cut-off grade for long-term planning of the copper open pits cite

  Kržanović Daniel, Kolonja Božo, Stevanović Dejan (2015)

  Kržanović Daniel, Kolonja Božo, Stevanović Dejan. "Maximizing the net present value by applying an optimal cut-off grade for long-term planning of the copper open pits" in Acta Montanistica Slovaca 20 no. 1, Kosice:Faculty of Mining, Ecology, Process Control and Geotechnologies (FBERG), Technical University of Kosice (2015): 49-61

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  Sedimentary sepiolite from the Andrici deposit (Pranjani basin, Serbia) cite

  Simić Vladimir, Suarez Mercedes, Garcia Romero E., Andrić Nevena (2012)

  Simić Vladimir, Suarez Mercedes, Garcia Romero E., Andrić Nevena. "Sedimentary sepiolite from the Andrici deposit (Pranjani basin, Serbia)" in Proceedings of the 29th IAS Meeting of Sedimentology, Schladming, Austria, 10th - 13th September, Leoben, Austria:International Association of Sedimentologists - IAS (2012): 333-333

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  E-Dictionaries and Finite-State Automata for the Recognition of Named Entities cite

  Krstev Cvetana, Vitas Duško, Obradović Ivan, Utvić Miloš (2011)

  Krstev Cvetana, Vitas Duško, Obradović Ivan, Utvić Miloš. "E-Dictionaries and Finite-State Automata for the Recognition of Named Entities" in Proceedings of the 9th International Workshop on Finite State Methods and Natural Language Processing, FSMNLP 2011, July 2010, Blois, France, A. Maletti and M. Constant (eds.), :Association for Computational Linguistics (2011): 48-56

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  Engineering geological and geotechnical investigations for design of higway E-80 Nis – Merdare cite

  Basarić Irena, Bogdanović Snežana, Rakić Dragoslav,Janković Jovana, Stevanović Miloš (2017)

  Basarić Irena, Bogdanović Snežana, Rakić Dragoslav,Janković Jovana, Stevanović Miloš. "Engineering geological and geotechnical investigations for design of higway E-80 Nis – Merdare" in 17th International Multidisciplinary Scientific Geoconference SGEM 2017/Conference Proceedings 12 no. 17, Albena: (2017): 279-287. https://doi.org/10.5593/sgem2107/

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  Opšti geotehnički uslovi izgradnje autoputa E-80 Niš – Merdare, Deonica: Niš – Pločnik - II Deo cite

  Rakić Dragoslav, Berisavljević Zoran, Basarić Irena, Lazić Mirko, Stevanović Miloš (2017)

  Rakić Dragoslav, Berisavljević Zoran, Basarić Irena, Lazić Mirko, Stevanović Miloš. "Opšti geotehnički uslovi izgradnje autoputa E-80 Niš – Merdare, Deonica: Niš – Pločnik - II Deo" in Zbornik radova sedmog naučno-stručnog međunarodnog savetovanja - Geotehnički aspekti građevinarstva, Šabac:Savez gradjevinskih inženjera Srbije (2017): 83-92

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  Opšti geotehnički uslovi izgradnje autoputa E-80 Niš – Merdare, Deonica: Niš – Pločnik - I Deo cite

  Rakić Dragoslav, Berisavljević Zoran, Basarić Irena, Lazić Mirko, Stevanović Miloš (2017)

  Rakić Dragoslav, Berisavljević Zoran, Basarić Irena, Lazić Mirko, Stevanović Miloš. "Opšti geotehnički uslovi izgradnje autoputa E-80 Niš – Merdare, Deonica: Niš – Pločnik - I Deo" in Zbornik radova sedmog naučno-stručnog međunarodnog savetovanja - Geotehnički aspekti građevinarstva, Šabac:Savez gradjevinskih inženjera Srbije (2017): 75-82