Претрага
4 items
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DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes
Aleksandar Mijatović, Angelina Caković, Aleksandar Lolić, Snezana Sretenović, Marko Živanović, Dragana Seklić, Jovana Bogojeski, Biljana Petrović (2023)Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV-Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1-3 also showed a possibility for DNA intercalation as well as a relatively high binding ability ...Aleksandar Mijatović, Angelina Caković, Aleksandar Lolić, Snezana Sretenović, Marko Živanović, Dragana Seklić, Jovana Bogojeski, Biljana Petrović. "DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O Schiff base copper(II) complexes" in Journal of the Serbian Chemical Society (2023). https://doi.org/10.2298/JSC230614063M
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Structure, interaction with biomolecules, and cytotoxicity of copper (II) complexes chelating some Schiff base ligands
Aleksandar Mijatović, Angelina Z. Caković, Aleksandar Lolić, Olivera Klisurić, Marko N. Živanović, Dragana S. Šeklić, Snežana Sretenović, Marija Ilić, Jovana Bogojeski (2023)Cancer remains one of the world's deadliest diseases, claiming many lives each day. Transition metal complexes are leading candidates in developing anticancer agens with cisplatin used in chemotherapy worldwide. Copper, an endogenous metal in the human body, is especially attractive because of its typical redox biological activities and a relatively strong affinity to nucleobases. A series of Cu(II) complexes with ethane-1,2-diamine as the amine part and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione, pentane-2,4-dione and/or 1,1,1- trifluoropentane-2,4-dione, or 1,1,1-trifluoropentane-2,4-dione and/or 1-phenylbutane-1,3-dione as the ...Aleksandar Mijatović, Angelina Z. Caković, Aleksandar Lolić, Olivera Klisurić, Marko N. Živanović, Dragana S. Šeklić, Snežana Sretenović, Marija Ilić, Jovana Bogojeski. "Structure, interaction with biomolecules, and cytotoxicity of copper (II) complexes chelating some Schiff base ligands" in Applied Organometallic Chemistry, Wiley (2023). https://doi.org/10.1002/aoc.7253
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Interactions of Copper(II) Complexes of some Schiff base ligands with calf thymus DNA and bovine serum albumin
Joni prelaznih metala u kombinaciji sa različitim ligandima nude veliki broj mogućnosti za ispitivanje potencijalnih bioaktivnosti. Među jonima prelaznih metala, bakar je poznat kao endogeni metal za ljude, sa karakterističnim biološkim redoks aktivnostima i relativno jakim afinitetom za nukleobaze. Kompleksi bakra ispoljavaju svoju antitumornu aktivnost na nekoliko različitih načina, generišu veliku količinu ROS, što uzrokuje oksidativno oštećenje mitohondrija i biomakromolekula. Nađeno je da kompleksi bakra(II) imaju umeren do dobar afinitet vezivanja sa DNK, uglavnom putem interkalacije.Angelina Petrović, Aleksandar Mijatović, Rada Baošić, Jovana Bogojeski. "Interactions of Copper(II) Complexes of some Schiff base ligands with calf thymus DNA and bovine serum albumin" in 6. Konferencija mladih hemičara Srbije, Srpsko hemijsko društvo (2018)
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Synopsis of the project “Development of Professional Courses in Sustainable Water Management”
Angelina Taneva-Veshoska, Zlatko Ilijovski, Ana Tomik, Dijana Likar-Dimishkovska, Maria Paula Mendes, Carolina Garcia Mata, Vesna Ristić Vakanjac, Dušan Polomčić, Dragoljub Bajić (2020)Angelina Taneva-Veshoska, Zlatko Ilijovski, Ana Tomik, Dijana Likar-Dimishkovska, Maria Paula Mendes, Carolina Garcia Mata, Vesna Ristić Vakanjac, Dušan Polomčić, Dragoljub Bajić . "Synopsis of the project “Development of Professional Courses in Sustainable Water Management” " in National Conference with international participation “Geosciences 2020”, Bulgaria, 2020., Bulgarian Geological Society (2020)