Претрага
6 items
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Рударско путовање по Србији спроведено 1835. године по налогу Владе Кнежевине Србије
Фон Хердер Сигмунд, Бегенишић Добрила, Здравковић Алена. Рударско путовање по Србији спроведено 1835. године по налогу Владе Кнежевине Србије, Београд Београд:ЈП Службени гласник, 2014: 165
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... dispersion was then transferred to 2 mL tubes containing 20%, 40%, or 60% v/v 0.1–0.2 mm yttrium stabilized zirconium beads (SiLibeads® Typ ZY-S, Sigmund Lindner GmbH, Warmensteinach, Germany) and shaken for 0.5 h or 1 h using a beads-milling cell disruptor equipment (Disruptor Genie, Scientific Industries ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals
Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić (2020)As the number of poorly soluble drugs is increasing, nanocrystals have become very interesting due to wide range of application possibilities. Curcumin was used as a model active ingredient in this work. Even though it has many proven positive effects, due to its physicochemical issues, its possibilities have not been fully exploited. The goal of this work was to select optimal conditions for a top-down method for curcumin nanosuspension production, and to perform their comprehensive characterization applying complementary methodologies: ...Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić. "Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals" in Review on advanced materials science, Walter de Gruyter GmbH (2020). https://doi.org/10.1515/rams-2020-0043
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... obtained dispersion was transferred to 2 ml Eppendorf tubes containing 60% v/v 0.1-0.2 mm yttrium-stabilized zirconium beads (SiLibeads8 type ZY-S, Sigmund Lindner, Germany). To reduce the particle size, the tubes were shaken for 1 h with a bead grinding cell disruptor (Disruptor Genie, Scientific ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557
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Mikroelementi u uljnim šejlovima Aleksinca i njihov uticaj na životnu sredinu
Nikoleta Aleksić (2021)... lake sediment using activated carbon and carbon nanotubes. Chemosphere 177, 65-76. https://doi.org/10.1016/j.chemosphere.2017.02.133. 9. Kah, M., Sigmund, G., Xiao, F., Hofmann, T., 2017. Sorption of ionizable and ionic organic compounds to biochar, activated carbon and other carbonaceous materials ...
... 381,37 440,04 36 190 4 Cink (Zn) 464,26 575,19 140 720 2 Kadmijum (Cd) 1,87 1,94 0,8 12 1 Olovo (Pb) 60,99 67,33 85 530 0 Klasa 0 – prirodni fon sedimenta, klasa 1 – neznatno zagađen sediment, klasa 2 – umereno zagađenje, klasa 3 – teško zagađen sediment; klasa 4 (4+)– ekstremno zagađen sediment ...Nikoleta Aleksić. "Mikroelementi u uljnim šejlovima Aleksinca i njihov uticaj na životnu sredinu" in VIII Memorijalni naučni skup iz zaštite životne sredine „Docent dr Milena Dalmacija“, 2021, Prirodno-matematički fakultet, Novi Sad (2021)
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Hidrogeoekološki uslovi eksploatacije kamenih i mrkih ugljeva Srbije
Branko R. Miladinović (2016-04-27)Ugalj predstavlja energent na čijoj osnovi se razvija privreda celog sveta.Zato mu se pridaje velika pažnja u eksploataciji i preradi, bez obzira na mnogeštetne uticaje na životnu sredinu, a posebno na efekat staklene bašte koji sestvara emisijom zagađujućih materija u atmosferu radom termoelektrana naugalj.U Srbiji, resurs koji se danas u najvećoj meri koristi u proizvodnjielektrične energije je ugalj i on učestvuje u proseku sa 70 %. U strukturi ukupneproizvodnje ugljeva, dominiraju lignitski ugljevi sa učešćem od 98 %, a ...Srbija, kameni i mrki ugalj, podzemna eksploatacija, preradauglja, rudničke vode, hemijski sastav, emisija zagađujućih materija, životnasredina... hatišerifa od 1830. godine, kada je Srbija dobila malu nezavisnost. Zato je bio angažovan u to vreme čuveni saksonski stručnjak rudarstva baron Herder, da poseti Srbiju i prouči njena rudna bogatstva. Očekivalo se da će njegovo angažovanje pomoći otvaranje prvih rudnika u Srbiji. Tako su krajem ...Branko R. Miladinović. "Hidrogeoekološki uslovi eksploatacije kamenih i mrkih ugljeva Srbije" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2016-04-27)