Претрага
253 items
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... following nanocrystal administration. Although results of the nanocrystals’ solubility (Figure 6b) did not promise improved pharmacokinetics, other factors such as permeability enhancement could give rise to better absorption [33]. Moreover, the pH value of the empty and fed Pharmaceutics 2021, 13, ...
... consequence of erratic or slower distribution, depot effect in the body, potential interaction with the brain lipids, or the combination of several factors. The structure of the blood-brain barrier is another piece of the complex puzzle when a drug is intended for brain delivery. Figure 8. Ratio between ...
... [CrossRef] [PubMed] 33. Imono, M.; Uchiyama, H.; Yoshida, S.; Miyazaki, S.; Tamura, N.; Tsutsumimoto, H.; Kadota, K.; Tozuka, Y. The elucidation of key factors for oral absorption enhancement of nanocrystal formulations: In vitro–in vivo correlation of nanocrystals. Eur. J. Pharm. Biopharm. 2020, 146, 84–92 ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Design of a sucker rod pumping system
Ana Ponoćko (2024)For a long time in the history of oil production, sucker rod pumps have been the first and in many cases the only choice when it comes to mechanical extraction methods. Proper selection of each individual element of the system enables optimization, which entails benefits in the form of increased efficiency and reduced costs. The first part of the paper presents the underground and surface equipment of the rod pump and describes the operation of the entire system. The ...... as the working conditions, including: maximum stress, the range of maximum and minimum stress, and the number of strokes per minute. All these factors affect material fatigue and the potential for rod failure,. In some cases, to reduce loads and investments in the lifting assembly and to increase ...
... driving the horsehead or rod pumps, the following drive motors are used — Gas Engines — Diesel Engines — Electric Motors When selecting a motor, factors to consider include: required power, load variation, source of the driving: medium, type of motor, type of installation, application constraints ...
... • CONCLUSION Designing a sucker rod pump system is a complex process that requires careful consideration of various technical and economic factors. Key aspects of this process include selecting ı the appropriate type of the pump, accurately determining the required power and capacity, and ensuring ...Ana Ponoćko. Design of a sucker rod pumping system, 2024
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An Approach to Management Decision Support: The Coal Mine Pljevlja Management Information System
In this paper we describe the approach that has been used in the development of the Management Information System (MIS) in the Coal Mine Pljevlja in Montenegro. The methodology of this approach was based on new information technologies and management techniques which have already been successfully applied in other related fields. Its main goal was to introduce modern management techniques to mining, adapted to specific features of the mining industry, its operations and environment, thus enabling the tactical management ...... Design and planning of these processes in the future needs to be closely integrated into more holistic mining systems, considering all controlling factors and impacts (technical, economic, environmental and social). It is crucial for the mining industry to develop a strategy for information technology ...Božo Kolonja, Ranka Stanković, Filip Vuković, Ivan Obradović. "An Approach to Management Decision Support: The Coal Mine Pljevlja Management Information System" in Proceedings of the Fifteenth International Symposium on Mine Planning and Equipment Selection, Torino, Italy, September 2006, Vol. 1,, Balkema (2006)
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Definition of Circulation Conditions and Groundwater Genesis of the Complex Krupaja Hydrogeological Karst System (Eastern Serbia)
Management, Monitoring, Policy and Law,Renewable Energy, Sustainability and the Environment, Geography, Planning and Development, Building and Construction... the potential to contribute significantly to defining, the genesis of groundwater in karst systems. Groundwater genesis is influenced by various factors such as precipitation Sustainability 2023, 15, 11146. https:/ /doi.org,/10.3390/su151411146 https:/ /www.mdpi.com/journal/sustainability Sust ...
... spatial model data, (C)—3D model of the conduit system of the Beljanica karst aquifer, (D)—Krupaja karst system spatial model detail. All of the factors mentioned above explain the possible groundwater genesis and circulation conditions. However, the genesis of the channel remains unknown, as well ...Ljiljana Vasić, Saša Milanović, Tina Dašić. "Definition of Circulation Conditions and Groundwater Genesis of the Complex Krupaja Hydrogeological Karst System (Eastern Serbia)" in Sustainability, MDPI AG (2023). https://doi.org/10.3390/su151411146
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Mitigating hydrate formation in onshore gas wells: A case study on optimization techniques and prevention
Gas wells, particularly those situated onshore, play a vital role in the global energy sector by supplying a significant portion of natural gas. However, operational challenges, notably gas hydrate formation, pose substantial issues, leading to complications such as flowline blockages and unexpected well shutdowns. Gas hydrates, crystalline structures resembling ice, ...Gas Well, Gas Hydrate Formation, Well Modeling, Well Performance Optimization, Choke Position Adjustments, Methanol InjectionMilica Ješić, Bojan Martinović, Stefan Stančić, Miroslav Crnogorac, Dušan Danilović. "Mitigating hydrate formation in onshore gas wells: A case study on optimization techniques and prevention" in Underground Mining Engineering, Beograd : Rudarsko-geološki fakultet (2023)
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GIS Application Improvement with Multilingual Lexical and Terminological Resources
... the latter being very important in highly inflective languages, such as Serbian. 1. Introduction Internationalization is one of the major factors currently influencing the application of geographic information systems (GIS) throughout the world. The research described in this paper is based ...Ranka Stanković, Ivan Obradović, Olivera Kitanović. "GIS Application Improvement with Multilingual Lexical and Terminological Resources" in Proceedings of the 5th International Conference on Language Resources and Evaluation, LREC 2010, Valetta, Malta, May 2010, Valetta, Malta : European Language Resources Association (2010)
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Formative evaluation of e-learning projects with the logical framework approach
... outputs, specific objectives (results), global goals (impacts); c. identification of "conditions" or "assumptions and risks" or "external factors" whose presence is indispensable for the realization of the causal chain. Figure 1: LFM's structure [24] Once filled the LFM, the project ...Roberto Linzalone, Giovani Schiuma, Ivan Obradović, Ranka Stanković. "Formative evaluation of e-learning projects with the logical framework approach" in The Sixth International Conference on e-Learning (eLearning-2015), September 2015, Belgrade, Serbia, Belgrade Metropolitan Univesity (2015)
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Development of integrated fuzzy model for mine management optimization
Miodrag Čelebić, Sanja Bajić, Dragoljub Bajić, Dejan Stevanović, Duško Torbica, Vladimir Malbašić (2023)... engineering. Decision making. requires the best possible knowledge about all the influencing, parameters of the ore deposit. In addition to natural factors, decisions about the mining: technology to be applied depend on technoeconomic aspects, ensuring of a safe and healthy work environment, and the ...Miodrag Čelebić, Sanja Bajić, Dragoljub Bajić, Dejan Stevanović, Duško Torbica, Vladimir Malbašić. "Development of integrated fuzzy model for mine management optimization" in Comptes rendus de l'Académie Bulgare des Sciences (2023)
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Conversion of land areas after coal mine closure and reclamation
Otkopavanje uglja površinski i podzemno praćeno je degradacijom zemljišta, promenom formiranja predela i izmenom flore i faune. Od velikog značaja je razvoj novih naučno utemeljenih pristupa obnovljanje antropogeno poremećenih predela zasnovanih na formiranju rekultivacionih i rudarskih tehnologija. Apsolutno je neophodno obezbediti sveobuhvatno kvalitetno očuvanje zemljišnih i vodnih resursa i odrediti rekultivisano zemljište za novu namenu. U ovom članku je dat pregled najpopularnijih metoda rekultivacije zemljišta i mogućnosti rekultivacije zemljišta nakon završetka rekultivacije i zatvaranja rudnika uglja.... the coal industry in the future, which requires more resources and effort. Further significant progress in the reclamation is related to several factors: • basic research, application of the sands, which would be the reclamation friendly and neutral for the natural environment, application of the ...Radmila Gaćina, Bojan Dimitrijević, Sanja Bajić. "Conversion of land areas after coal mine closure and reclamation" in 9th International conference mining and environmental protection MEP 23 Proceedings, Sokobanja, 24-27.05.2023., Belgrade : University of Belgrade - Faculty of mining and geology (2023)
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Hidrogeohemijska valorizacija esencijalnih mikroelemenata mineralnih voda Srbije
Jana S. Stojković (2013-09-25)Mineralne vode još od davnina privlače pažnju ljudi i to kako u pogledu istraživanja iproučavanja, tako i u pogledu njihovog iskorišćavanja. Naročito je važno poznavanjesadržaja mikroelemenata u njima, jer su to komponente njihovog hemijskog sastavakoje ih odvajaju od tzv. „običnih“ malomineralizovanih voda.U ovom radu proučavani su odabrani esencijalni mikroelementi (fluor, bor, litijum,kalijum, stroncijum i silicijum), u mineralnim vodama Srbije, pri čemu je analiziranopreko 130 uzoraka mineralnih voda iz različitih geoloških sredina, to jest hidrogeološkihrejona. Cilj ovog istraživanja bio je ...esencijalni mikroelementi, faktori migracije, zakonomernosti rasprostranjenja, hidrogeohemijski procesi, multivarijantna statistička analiza, mineralne vode Srbije... of 14 chemical parameters measured on 110 mineral water samples from Serbia, three factors were extracted, which explain 67.4 % of the total variance in the analyzed dataset. The interpretation of obtained factors has Jana S. Stojković Doktorska disertacija vii indicated several hydrog ...
... . By systematizing the results of this research the following conclusions have been drawn: The joined effect of all three extracted factors results in appearance of higher concentration of all analyzed microelements. This is the case in thermal carbonated mineral waters appearing in ...
... The assumption about paragenesis of the considered microelements has been confirmed by this fact. The domination of each of the extracted factors has been caused by the position of the important geological structures on the Serbian territory. The first factor is dominant at mineral water ...Jana S. Stojković. "Hidrogeohemijska valorizacija esencijalnih mikroelemenata mineralnih voda Srbije" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2013-09-25)
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Анализа утицаја искоришћења у преради на резултате оптимизације површинских копова
Стефан Митић (2024)Одређивање оптималних граница површинског копа је сложен и итеративни процес који захтева мултидисциплинарну експертизу, софистициране технике анализе и пажљиво разматрање геолошких, рударских, економских,техничких, еколошких и друштвених фактора. Оптимизација подразумева генерисање серије шкољки, површинског копа на основу различитих фактора прихода (Revenue factor) са итеративним кораком промене цене метала у односу на базну цену. Свака генерисана шкољка представља инкрементално повећање запремине резерви према инкременталном повећању продајне цене метала. Велики број техно -економских фактора утиче на овај процес, и промена сваког од њих ...оптимизација површинског копа, анализа границе копа, оптимална контура копа, лежиште Бувач, профит, искоришћење у преради, трошкови прераде руде... 25 10 2022 iii — RuetenceMiingCost |28 [7 + Sehng | MningRecoven Faiom |0 965 MninoDiiuton Fractor: |01 presoe - Biock hig Cost Adjustment Factors ONone (8 Mođel CCalculate: - Rock Type Detait: ocktpo Viring Rozevorf Fraclon Mnng Diiwion Fract n 77 Renab Coct |} | | 096 f.| [] | T T og ...
... Shells) je omaja Kaja ce Kao pe3ynrar OHnTHMMM3amHje KpeHpa CcepHja CyKHeCHBHHX KONOBa HO OOMHMy H BpeJIHOCTH, IIpHMCHOM (bakTopa rnpuxona (Revenue factors). 3a JenHy (bMKcHy HeHy TIpOH3BOJ/UA, HPDOHeCOM OHTHMMH3amHje JUOOMJa cc jenHa OHTMMJIHA. KOHTypa KOMa. IIpomec onrHMMmaanuje y Whittle coprBepy ...
... ConstaFts | Fe đonne) oR II 581 # LE a| |eeay Ppresions | |D M GD 42 |' UserBement | E omne) o Ž || as 50 773 Hepot Biock processing cost adlustment factors | ONone (8)Modal C Calculate: | processing Path Groups Name Defnilon CheckData Cnnuka 4.15. Ianen ynoca no0oamak 3a onmuMu3auyujy 3aTHM Ce ...Стефан Митић. Анализа утицаја искоришћења у преради на резултате оптимизације површинских копова, 2024
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Flyrock induced by blasting in surface mining
Milanka Negovanović, Lazar Kričak, Snežana Ignjatović, Stefan Milanović, Jovan Marković, Nikola Simić, Rade Šarac (2022)Miniranje predstavlja i dalje najefikasniji i najjeftiniji način eksploatacije velikih količina čvrstih mineralnih sirovina na površinskim kopovima. Energija eksplozije se koristi za fragmentaciju čvrste stenske mase do zahtevane granulacije. Pored pozitivnih efekata miniranja, postoje i određeni neželjeni efekti svakog procesa miniranja koji se mogu javiti, a to su: potresi tla, razletanje komada stene, vazdušni udari, otrovni i zagušljivi gasovi i prašina. Razletanje komada stene je nekontrolisano izbacivanje fragmenata odminirane stenske mase i predstavlja jedan od glavnih izvora materijalne štete ...Milanka Negovanović, Lazar Kričak, Snežana Ignjatović, Stefan Milanović, Jovan Marković, Nikola Simić, Rade Šarac. "Flyrock induced by blasting in surface mining" in Rudarski glasnik, Beograd : Rudarski institut (2022). https://doi.org/10.25075/BM.2022.05
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A hydrogeological model of the open-cast mine Tamnava - West Field (Kolubara Coal Basin, Serbia)
... the porous medium and hydrodynamic state of aquifer flow, - aquifer regime, which is determined by certain laws, phenomena and distribution of factors, - water balance components, - boundary conditions (inflow into and outflow from the model), and - initial conditions, determined by the piezometric ...Jelena Ratković, Dušan Polomčić, Dragoljub Bajić, Bojan Hajdin. "A hydrogeological model of the open-cast mine Tamnava - West Field (Kolubara Coal Basin, Serbia)" in Underground Mining Engineering no. 29, Belgrade : University of Belgrade - Faculty of mining and geology (2016): 43-54
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3D modeling and monitoring of karst system as a base for its evaluation and utilization: a case study from eastern Serbia
Earth-Surface Processes, Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary ChangeSaša Milanović, Zoran Stevanović, Ljiljana Vasić, Vesna Ristić-Vakanjac. "3D modeling and monitoring of karst system as a base for its evaluation and utilization: a case study from eastern Serbia" in Environmental Earth Sciences, Springer Science and Business Media LLC (2013). https://doi.org/10.1007/s12665-013-2591-9
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Distribution of major and trace elements in the Kovin lignite (Serbia)
Dragana Životić, Olga Cvetković, Predrag Vulić, Ivan Gržetić, Vladimir Simić, Konstantin Ilijević, Biljana Dojčinović, Suzana Erić, Bogdan Radić, Sanja Stojadinović, Snežana Trifunović (2019)geochemical and mineralogical study was performed on lignite samples from the Upper Miocene Kovin deposit, hosting three coal seams. The Kovin lignite is characterized by high moisture content, medium to high ash yield, medium to high sulphur content and a relatively low gross and net calorific value. The mineralogical composition, and major and trace element contents were determined by X-ray diffraction, scanning electron microscopy with energy dispersive Xray spectroscopy (SEM-EDS) analyses, and inductively coupled plasma optical emission spectrometry (ICP-OES). ...... influenced by water level, regional depositional and paleoenvironmental factors, which control the enrichment or depletion of the different ele ments and mineral phases contained in the coal. Chemical, bio logical and physical factors in mire systems provide specific en vironments in which minerals could ...
... material to this paper. G eo lo g ia C ro a ti ca Geologia Croatica 72/162 (GLUSKOTER, 1975; TAYLOR et al., 1998; WARD, 2016). Epi genetic factors may also influence the variation in elements (CHRISTANIS et al., 1998; KALAITZIDIS et al., 2002; DAI et al., 2012). The modes of mineral occurrences ...
... Geology, 100, 1–13. doi: 10.1016/j.coal.2012.05.009 CHRISTANIS, K., GEORGAKOPOULOS, A., FERNÁNDEZTURIEL, J.L. & BOUZ INOS, A. (1998): Geological factors influencing the concentration of trace ele ments in the Philippi peatland, eastern Macedonia, Greece.– International Journal of Coal Geology, 36 ...Dragana Životić, Olga Cvetković, Predrag Vulić, Ivan Gržetić, Vladimir Simić, Konstantin Ilijević, Biljana Dojčinović, Suzana Erić, Bogdan Radić, Sanja Stojadinović, Snežana Trifunović. "Distribution of major and trace elements in the Kovin lignite (Serbia)" in Geologia Croatica, Croatian Geological Survey (2019). https://doi.org/10.4154/gc.2019.06
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Overwiew of In-Pit Crushing & Conveying Technology in Open Pit Mines
The conditions under which contemporary surface mining operations is carried out obviously becoming increasingly complex. In such complex conditions, the optimization of haulage systems as the technological phase with the largest share in the total operating costs, is very important from the aspect of achieving profitability of the mining project. In a large number of cases, the application of traditional haulage systems with trucks (as the most dominant type of haulage in open pit mines) does not lead to ...Ali Nasirinezhad, Dejan Stevanović, Dragan Ignjatović, Petar Marković. "Overwiew of In-Pit Crushing & Conveying Technology in Open Pit Mines" in 8th International Conference MIining And Environmental Protection, Sokobanja, 22-25 September 2021, University of Belgrade, Faculty of Mining and Geology, Belgrade, Serbia (2021)
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Available technological procedures for capturing CO2 in the industrial and power generation sectors
Climate change is a major environmental issue caused by anthropogenic emissions of greenhouse gases. Capturing CO2 and storing it in suitable geological formations is one of the main technological solutions that can provide mitigation of CO2 emission into the atmosphere. Capturing CO2 represents the first phase in process of carbon capture and storage, and includes the application of various technologies for the separation of CO2 produced in the energy and industrial sectors. There are four main systems for capturing ...... most expensive phase in CCS process and it accounts for approximately 75% of overall costs. The selection of CO2 capture systems depends on more factors. Post-combustion CO2 capture is the most mature option, and it can be integrated into existing power plants. The main disadvantage of post- combustion ...Lola Tomić, Vesna Karović Maričić, Dušan Danilović, Branko Leković, Miroslav Crnogorac. "Available technological procedures for capturing CO2 in the industrial and power generation sectors" in 8th International Conference Mining and Environmental Protection, 22 – 25th September 2021, Serbia, Univerzitet u Beogradu, Rudarsko-geološki fakultet (2021)
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Part of Speech Tagging for Serbian language using Natural Language Toolkit
Ranka Stanković, Boro Milovanović (2020)Dok se razvijaju složeni algoritmi za NLP (obrada prirodnog jezika), osnovni zadaci kao što je označavanje ostaju veoma važni i još uvek izazovni. NLTK (Natural Language Toolkit) je moćna Python biblioteka za razvoj programa zasnovanih na NLP-u. Pokušavamo da iskoristimo ovu biblioteku za kreiranje PoS (vrsta reči) oznake za savremeni srpski jezik. Jedanaest različitih modela je kreirano korišćenjem NLTK API-ja za označavanje. Najbolji modeli se transformišu sa Brill tagerom da bi se poboljšala tačnost. Obučili smo modele na označenom ...... tagging practice for the training and evaluation sets. In the process of preparing data, there are multiple tagsets and annotators. This is too many factors for an automated tagger to have the performance near maximum. Although no research is conducted using different NLP tool and the exact same resources ...Ranka Stanković, Boro Milovanović. "Part of Speech Tagging for Serbian language using Natural Language Toolkit" in 7th International Conference on Electrical, Electronic and Computing Engineering IcETRAN 2020, Academic Mind, Belgrade (2020)
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Groundwater gravitational circulation of Karst Veliko Vrelo and Malo Vrelo springs by isotope and the noble gas method: case study of the Beljanica Massif
Earth-Surface Processes, Geology, Pollution, Soil Science, Water Science and Technology, Environmental ChemistryLjiljana Vasić, Laszlo Palcsu, Huang Fen. "Groundwater gravitational circulation of Karst Veliko Vrelo and Malo Vrelo springs by isotope and the noble gas method: case study of the Beljanica Massif" in Environmental Earth Sciences, Springer Science and Business Media LLC (2019). https://doi.org/10.1007/s12665-019-8294-0
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Digitalizacija u rudarstvu: Kreiranje sistema za efikasno poslovno izveštavanje
Proces donošenja odluka u oblasti rudarstva i geologije uslovljen je blagovremenim posedovanjem kvalitetnih podataka i informacija. Kompleksnost rudarskih procesa nalaže prikupljanje podataka na dnevnom odnosno na smenskom nivou. Podaci kao takvi bez analitičkog pristupa nisu dovoljni. Kako bi pristup podacima bio brz i efikasan neophodno je posedovanje adekvatnog digitalnog rešenja uz adekvatne centralizovane baze podataka. U ovom radu je dat pregled trenutne pozicije rudarstva sa aspekta digitalne transformacije kao i predlog jednostavnog prototipa u obliku digitalnog sistema za poslovno ...... Strategy & Leadership, 40, s. 16-24. [7] Wolf, M., Semm, A. & Erfurth, C. (2018). Digital transformation in companies-challenges and success factors. In Innovations for Community Services: Išth International Conference, I4CS 2018, Žilina, Slovakia, pp. 178-193. [8] Earley S. (2014). The digital ...Stevan Đenadić, Aleksandar Mirković, Veljko Rupar . "Digitalizacija u rudarstvu: Kreiranje sistema za efikasno poslovno izveštavanje" in XVI Međunarodna rudarska konferencija OMC 2024, Zlatibor, 9 - 12. oktobar 2024, Jugoslovenski komitet za površinsku eksploataciju (2024)