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2159 items
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Influence of paleoenvironmental conditions on distribution and relative abundance of saturated and aromatic hydrocarbons in sediments from the NW part of the Toplica basin, Serbia
Nikola Burazer, Aleksandra Šajnović, Nebojša Vasić, Milica Kašanin-Grubin, Dragana Životić, João Graciano Mendonça Filho, Predrag Vulić, Branimir Jovančićević (2020)Nikola Burazer, Aleksandra Šajnović, Nebojša Vasić, Milica Kašanin-Grubin, Dragana Životić, João Graciano Mendonça Filho, Predrag Vulić, Branimir Jovančićević. "Influence of paleoenvironmental conditions on distribution and relative abundance of saturated and aromatic hydrocarbons in sediments from the NW part of the Toplica basin, Serbia" in Marine and Petroleum Geology, Elsevier BV (2020). https://doi.org/10.1016/j.marpetgeo.2020.104252
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Projection of SO2 emissions in coal power plants in Serbia
Aleksandar Madžarević, Predrag Jovančić, Stevan Đenadić, Filip Miletić, Miodrag Ristović, Miroslav Crnogorac (2023)The production of electricity in the countries of South-Eastern Europe (SEE) was mainly related to the use of coal, predominantly lignite. The total installed capacity of thermal power plants using coal in these seven countries is 17.813 MW, distributed in 31 thermoblocks. The mentioned plants are the dominant pollutant emitters in all observed countries. Data on the largest emitters in the countries of the European Union and a comparison with SEE countries were collected. The calculation of emissions of ...... pollutants and gases from coal-fired thermal power plants has always been a must. Coal production in Europe is steadily declining. In 2010, it was 835 Mt to 516 Mt in 2021. Recent events of a political and economic nature on the soil of Europe have influenced the intensity of the change in energy ...
... online: https://data.worldbank.org/topic/energy- and-mining?view=chart EUROSTAT, Eurostat regional yearbook 2016, 2016. Available online: https://ec.europa.eu/statistical-atlas/viewer/?config=RYB-2016.json& Framework Convention on Climate change, Conference of the Parties, Twenty-first session ...
... of Belgrade, Faculty of Mining and Geology, Belgrade, SERBIA, E-mail: aleksandar.madzarevic(orgf.bg.ac.rs ! University of Belgrade, Faculty of Mining and Geology, Belgrade, SERBIA, E-mail: predrag.jovancicOrgf.bg.ac.rs ! University of Belgrade, Faculty of Mining and Geology, Belgrade, SERBIA, E-mail: ...Aleksandar Madžarević, Predrag Jovančić, Stevan Đenadić, Filip Miletić, Miodrag Ristović, Miroslav Crnogorac. "Projection of SO2 emissions in coal power plants in Serbia" in 9th International Conference Mining and environmental protection, Sokobanja 24-27th May 2023., Belgrade : University of Belgrade, Faculty of Mining and Geology (2023)
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Geotehnički efekti razaranja komunalnog otpada različitim postupcima zbijanja
Jovana M. Janković Pantić (2022)Odlaganje otpada na komunalne deponije predstavlja osnovni način zbrinjavanja otpada u Srbiji. Kako bi se prostor za deponovanje materijala racionalno koristio potrebno ga je svakodnevno zbijati sa unapred definisanom količinom vode koja se dodaje. Dobro zbijeni komunalni otpad zauzima manju zapreminu i omogućuje sigurnije skladištenje, pa je korisno prethodno laboratorijski odrediti parametre zbijanja: maksimalnu suvu zapreminsku težinu (dmax) i optimalnu vlažnost (wopt). U Srbiji do sada nisu određivani parametri zbijanja, dok je u svetu primenjivana standardna metoda (Proktorov opit) ...Jovana M. Janković Pantić. Geotehnički efekti razaranja komunalnog otpada različitim postupcima zbijanja, Beograd : [J. Janković Pantić], 2022
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Long-term planning methodology for improving wood biomass utilization
The insufficiently developed forest management system is often followed by undeveloped forest resources supply chain and insufficient institutional support. These cause inefficient usage of fuel-wood as well as huge amounts of unused forest residues. In order to achieve optimal and long-term sustainable utilisation of biomass, an original methodology based on the interaction of mathematical optimization and backcasting approach has been developed. Mathematical optimization is used for both generation and consideration of techno-economic parameters of the forest biomass supply chain. ...Vladimir Vukašinović, Dušan Gordić, Marija Živković, Davor Koncalović, Dubravka Živković. "Long-term planning methodology for improving wood biomass utilization" in Energy, Elsevier BV (2019). https://doi.org/10.1016/j.energy.2019.03.105
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Substitution reactions of some novel sterically hindered monofunctional Pd(II) complexes
Reakcije supstitucije monofunkcionalnih kompleksa [(TLtBu)PdCl]+ i [Pd(tpdm)Cl]+, gde je TLtBu = 2,6-bis[(1,3-di-terc-butilimidazolin-2-imino)metil]piridin i tpdm = terpiridindimetan, sa nukleofilima kao što su: tiourea, I−, Br−, NO2−, piridin i dimetil-sulfoksid (DMSO) proučavani su u 0,1 M vodenom rastvoru NaClO4 u prisustvu 10 mM NaCl. Reakcije su sprovedene na tri različite temperature (288, 298 i 308 K) korišćenjem tehnike zaustavljenog protoka na različitim temperaturama. Reakcije supstitucije su praćene pod uslovima pseudo prvog reda sa velikim viškom nukleofila. Dobijeni rezultati pokazuju da kompleks ...... reactions of [(TLtBu)PdCl]+ and [Pd(tpdm)Cl]+ complexes were initiated by mixing equal volumes of complex and ligand solutions directly in the stopped-flow instru- ment and the reaction was followed for at least eight half-lives. The substitution process was monitored as change in absorbance with time under ...
... reactions of [(TL®")Pdcl]* and [Pd(tpdm)Cl]* complexes were initiated by mixing equal volumes of complex and ligand solutions directly in the stopped-flow instru- ment and the reaction was followed for at least eight half-lives. The substitution process was monitored as change in absorbance with time under ...
... 3. Kinetic measurements The substitution reactionsof the [(TLtBu)PdCl]+ and [Pd(tpdm)Cl]+ complexes with the nucleophiles: thiourea, I�, Br�, NO2 �, pyridine and DMSO were studied spectrophotometrically by following the change in absorbance at suitable wavelengths as a function of time. Spectral changes ...Aleksandar Mijatović, Jovana Bogojeski, Biljana Petrović, Živadin D. Bugarčić. "Substitution reactions of some novel sterically hindered monofunctional Pd(II) complexes" in Inorganica Chimica Acta, Elsevier BV (2011). https://doi.org/10.1016/j.ica.2011.11.031
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Review: Methodological approaches and research techniques for addressing construction and remediation problems in karst reservoirs
Saša Milanović, Ljiljana Vasić (2021)Saša Milanović, Ljiljana Vasić. "Review: Methodological approaches and research techniques for addressing construction and remediation problems in karst reservoirs" in Hydrogeology Journal, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s10040-020-02280-1
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Threshold-induced correlations in the Random Field Ising Model
... exactly the value that triggers only the least stable spin. Note, however, that because all spins during the foregoing change remain stable, and therefore unaltered, the overall change of H is allowed to be done in a single jump, which is utilized in computer simulations for better e�ciency. �e consequence ...
... exactly the value that triggers only the least stable spin. Note, however, that because all spins during the foregoing change remain stable, and therefore unaltered, the overall change of H is allowed to be done in a single jump, which is utilized in computer simulations for better efficiency. The consequence ...
... making an avalanche which lasts until all spins become stable. Once all spins become stable, the only way to trigger a new avalanche is to change the external �eld H, and in this way drive the system by a sequence of H-increments, forming a driving pattern that is set in advance. Typically, the changes ...Sanja Janićević, Dragutin Jovković, Lasse Laurson, Đorđe Spasojević. "Threshold-induced correlations in the Random Field Ising Model" in Scientific Reports, Springer Science and Business Media LLC (2018). https://doi.org/10.1038/s41598-018-20759-6
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Why classical sequence stratigraphy doesn't work in Pannonian basin?
Dejan Radivojević (2018)... the context of the formation of tectonically and climatically controlled rift cycles. With interpretation of tectonic systems tract and well data correlation one can clearly notice that extension is diachron and that stretching factor change along regional transect. Some areas expe‐ rien ...
... Constraining forcing factors and relative sea‐level fluctuations in semi‐enclosed basins: The Late Neogene demise of Lake Pannon, Basin Research doi: 10.1111/bre.12094. Vail, P.R., R.M. Mitchum, K.M. Campion, V.D. Rahmanian, 1977. Seismic Stratigraphy and Global Changes of Sea Level, Part 3 ...
... tional sequences. MATERIAL AND METHODS The regional composite seismic transect (figure 1) with length of more than 260 km at which rift sequence stratigraphy method is demonstrated is made to determine the range of base level change, as well as tectonic and sedimentary relationships. The ...Dejan Radivojević. "Why classical sequence stratigraphy doesn't work in Pannonian basin?" in 17th Serbian Geological Congress, Vrnjačka Banja, 17-20 maj 2018, Srpsko geološko društvo (2018)
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Effects of external noise on threshold-induced correlations in ferromagnetic systems
Dragutin Jovković, Sanja Janićević, Svetislav Mijatović, Lasse Laurson, Đorđe Spasojević. "Effects of external noise on threshold-induced correlations in ferromagnetic systems" in Physical Review E, American Physical Society (APS) (2021). https://doi.org/10.1103/PhysRevE.103.062114
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Modeliranje i simulacija energetske tranzicije u sektoru domaćinstava
Boban S. Pavlović (2022)Aktuelnu energetsku tranziciju odlikuje ubrzanje procesa dekarbonizacije energetskih sistema, unapređenje energetske efikasnosti, razvoj čistijih tehnologija baziranih na obnovljivim izvorima energije i održivije korišćenje prirodnih resursa. Da bi se napravio ovako krupan zaokret u postojećim energetskim sistemima, osim promene postojećih tehnologija, potrebno je u planiranje energetske tranzicije uključiti i političke, sociološke, ekonomske i ekološke aspekte, a pre svega obrasce ponašanja i donošenja odluka krajnjih potrošača. Predmet istraživanja u disertaciji je energetska tranzicija sektora domaćinstva, preciznije tranzicija u grejanju domaćinstava, imajući u ...energetika, energetska tranzicija, energetsko planiranje, energetsko modeliranje, obnovljivi izvori energije, domaćinstva, ponašanje potrošačaBoban S. Pavlović. Modeliranje i simulacija energetske tranzicije u sektoru domaćinstava, Beograd : [B. Pavlović], 2022
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Comprehensive Profiling of Microbiologically Induced CaCO3 Precipitation by Ureolytic Bacillus Isolates from Alkaline Soils
Olja Šovljanski, Lato Pezo, Jovana Stanojev, Branimir Bajac, Sabina Kovač, Elvira Tóth, Ivan Ristić, Ana Tomić, Aleksandra Ranitović, Dragoljub Cvetković, Siniša Markov (2021)MICP process, kinetic study, calcite, vaterite, MALDI-TOF identification, Bacillus licheniformis, Sporosarcina pasteurii... active and passive CaCO3 formation), the MICP process is a consequence of carbonate production by ion transport across cellular membrane and reactivity of calcium ions accumulation on the surface of negatively charged bacterial walls [9]. Furthermore, the whole process is reflected in a change of pH value ...
... growth on Urea agar (UAG), Urea agar color change (UAC), Urea broth turbidity (UBT), Urea broth color change Microorganisms 2021, 9, 1691 4 of 20 (UBC), addition of CaCl2 in inoculated Urea broth (UBCA), CaCO3 formation on/in Urea- CaCl2 medium (MUC), and CaCO3 formation on/in YE-CaCl2 medium (MEC) ...
... period of 7 days at 30 ◦C, the turbidity, color change (equivalent to pH changes), and addition of 3.2 g/L CaCl2 (rapid test for precipitation) were observed in the Urea base broth. The precipitation of inorganic deposits was observed in Urea-CaCl2 and YE-CaCl2 broth. A total volume of inoculated media ...Olja Šovljanski, Lato Pezo, Jovana Stanojev, Branimir Bajac, Sabina Kovač, Elvira Tóth, Ivan Ristić, Ana Tomić, Aleksandra Ranitović, Dragoljub Cvetković, Siniša Markov. "Comprehensive Profiling of Microbiologically Induced CaCO3 Precipitation by Ureolytic Bacillus Isolates from Alkaline Soils" in Microorganisms, MDPI AG (2021). https://doi.org/10.3390/microorganisms9081691
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Maturation and isotopic changes of individual hydrocarbons in lignite lithotypes through diagenesis and early catagenesis
... have very close values in pyrolysates and lignite extracts, confitrming that ıisotopic signatures аге useful tracers for alteration ts of biological molecules. Long-chain homologues exhibit slight enrichment in 7С from Pyr400 to Pyr500, whereas almost no change 15 detected in 515C ог short-chain m-alkanes ...
... fractions of lignite extracts and pyrolysis prođucts are садајепе and retene. The matunty ratios based оп trimethyinaphthalenes (ТММЕ) and tetramethyinaphthalenes (TeMNr) slightly increase from Pyr400 to Pyr500. The same 15 тејајед to methylfluorene (МЕ) гано (2-+3-MF)/(1-+4-MF) and methyiphenanthrene (МР) ...
... Faculty of Mining and Geology archives faculty publications available in open access, as well as the employees' publications. - The Repository is available at: www.dr.rgf.bg.ac.rs MATURATION AND ISOTOPIC СНАМСбЕ5 ОЕ INDIVIDUAL HYDROCARBONS IN LIGNITE LITHOTYPES THROUGH DIAGENESIS AND EARLY CATAGENESIS ...Ivan Kojić, Achim Bechtel, Reinhard Sachsenhofer, Dragana Životić, Ksenija Stojanović. "Maturation and isotopic changes of individual hydrocarbons in lignite lithotypes through diagenesis and early catagenesis" in 29th International Meeting on Ogranic Geochemistry, 1-6 September 2019, Gothenburg, Sweden , European Association of Organic Geochemists (2019)
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The influence of Al<sup>3+</sup>ion on porcine pepsin activity<i>in vitro</i>
The in vitro effect of Al3þ ions in the concentration range 1.7·1026M–8.7·1023M on pepsin activity at pH 2, via kinetic parameters and its electrophoretic mobility was evaluated. Kinetic study demonstrated the existence of an activation effect of Al3þ at pH 2 on pepsin molecule. Kinetic analysis with respect to concentrations of haemoglobin showed that Al3þ ions increase the maximal velocity (Vmax) and kcat values rather than apparent affinity for substrate (KS) implying the non-competitive nature of activation which indicated ...... reciprocal of the change in slope and intercept (Aslope and Aintercept) that are determined by subtracting the values in the presence of activator from that in its absence, are linear [29,30]. "The intercepts ofa plot 1/Aslope and 1/Aintercept vs. 1/ [AF** ] on 1/A axis, and intercepts of both ...
... mobility of pepsin molecule may be assigned to the change in net electric charge of the pepsin caused by binding of Al'* ions to corresponding binding sites of pepsin molecule and probably to conformational changes evaluated by UV and IR spectroscopy. The obtained effect is pro- portional ...
... Vy x values, without producing a significant change in the value of apparent enzyme affinity for substrate (Ks). The results obtained from Lineweaver-Burk plots, are used for calculation of kinetic constants. The secondary plots ofthe slopes and intersects vs. activator concentrations are not ...Vesna M. Pavelkić, Kristina R. Gopcević, Danijela Z. Krstić, Marija A. Ilić. "The influence of Al3+ion on porcine pepsin activityin vitro" in Journal of Enzyme Inhibition and Medicinal Chemistry, Informa UK Limited (2008). https://doi.org/10.1080/14756360701841095
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An Approach to Management Decision Support: The Coal Mine Pljevlja Management Information System
In this paper we describe the approach that has been used in the development of the Management Information System (MIS) in the Coal Mine Pljevlja in Montenegro. The methodology of this approach was based on new information technologies and management techniques which have already been successfully applied in other related fields. Its main goal was to introduce modern management techniques to mining, adapted to specific features of the mining industry, its operations and environment, thus enabling the tactical management ...... important. Technological change is not simply the implementation of new machines, computers and software. Technology should be employed to plan, design and operate differently, to be better informed and intelligent in decision-making, more efficient in operation, safer, and more responsible to society ...
... managers’ reporting needs are modeled through by a global model of data related to the most important business segments (production, maintenance, operative costs, etc.). MIS presents updated and precise data to the managers of the company in a clear and synoptic way. It is necessary that all the operative ...
... entities, job classification, all kinds of decisions pertaining to labour relations, change of workplace, etc.); reporting on labour relations (enquiries about an employee, statistical reviews on various basis, internal and external reports, etc.) 2.2 Technical database management The system for technical ...Božo Kolonja, Ranka Stanković, Filip Vuković, Ivan Obradović. "An Approach to Management Decision Support: The Coal Mine Pljevlja Management Information System" in Proceedings of the Fifteenth International Symposium on Mine Planning and Equipment Selection, Torino, Italy, September 2006, Vol. 1,, Balkema (2006)
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Mineral Resources of Serbia: Environmental, Societal and Economic Challenges
... of Serbia, as well as international projects. “Education, Research and Training for Global Environmental Change and Sustainable Management of Natural Resources in Western Balkans *, Norway and others. Jela Ikanović, PhD Research Associate, Assistant Professor Affiliation: University of Belgrade ...
... of water resources. AITR POLLUTION, CLIMATE CHANGE AND RELATED ADVERSE HEALTH EFFECTS Respirable particulate matter, ozone and inorganic gaseous pollutants comprise a global public health issue associated with a wide range of adverse effects and premature mortality Complimentary Contributor ...
... point of the global climate change which has not avoided the agricultural regions of Serbia. The aim of this study was to determine the influence of semi-arid ecological environmental factors of central Serbia on the winter triticale varieties and their differences in stability and adaptability ...Vladimir Simić, Rade Jelenković, Dragana Životić. "Mineral Resources of Serbia: Environmental, Societal and Economic Challenges" in Serbia: Current Issues and Challenges in the Areas of Natural Resources, Agriculture and Environment,, Nova Science Publishers, Inc. (2019)
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Numerical modeling of Selanac debris flow propagation using SPH code
The Selanac debris flow is a very huge event triggered after extreme rainfall caused by Cyclone Tamara activity in the Republic of Serbia in May 2014. The Selanac case study was already modelling in different programs using Voellmy rheology assumptions like RAMMS software. In this paper research are focusing particularly on the process of debris flowing from initiation zone to main deposition area using Geoflow SPH two-phase model considering frictional rheology law. Main rheological parameters are back-calculated using also ...... results show heights and volume change as well as depths of eroded material, which are in accordance with previous research results. It can be concluded that the SPH simulation model is capable to obtain reasonable results and properly back-calculate the deposition depth and run-out distance. ...
... Location of case study B) geometry and main parts 3 METHOD SPH (Smoothed Particle Hydrodynamics) was firstly proposed by Lucy (1977) and Gingold and Monaghan (1977) and applied in astrophysical modeling. In time, it became widely used in different fields (Liu and Liu 2010; Chen et al. 1996; Huang ...
... fields of research, and it is found very suitable in different parts of fluid mechanics. Its main difference from other most used methods like finite element and finite difference methods, is in absence of numerical grid, and while mass is presented with particles of solid and fluid phase. Each particle ...Jelka Krušić, Biljana Abolmasov, Miloš Marjanović, Manuel Pastor, Saeid M. Tayyebi . "Numerical modeling of Selanac debris flow propagation using SPH code" in SCG-XIII International Symposium on Landslides. Cartagena, Colombia- February 22-26, 2021, International Society for Soil Mechanics And Geotechnical Engineering (2021)
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The Fuzzy–AHP Synthesis Model for Energy Security Assessment of the Serbian Natural Gas Sector
Natural gas is used for the production of almost 20% of total energy today. The natural gas security of the Republic of Serbia is an urgent strategic, political and security issue. Serbia is one of the most vulnerable countries in Southeast Europe, because it only has one supply route. This study is a contribution to efforts to better understand the factors affecting energy security through the implementation of a new methodology based on the fuzzy–AHP synthesis model for measuring ...... wealth and availability of energy resources and their usage by type and intensity are taken into account. In addition, economic growth, demographic indicators, political priorities, market development, and energy scenarios have important roles [13–16]. Changing strategic priorities causes change in the ...
... for the purpose of assessing the impact of climate change policy and relevant policy measures, because in addition to assessing different energy development scenarios, it also provides assessments on climate change mitigation policy and climate change adaptation, with the possibility of assessing their ...
... approximately 600 million m3 in the 1970s and the 1980s, and it has never achieved 20% of total Symmetry 2020, 12, 908 13 of 42 consumption [68]. The Company NIS becomes NIS Gazprom Neft after change of ownership in 2009. It introduced a new business course and investment in modern technology [67]. This ...Aleksandar R. Madžarević, Dejan D. Ivezić, Miloš L. Tanasijević, Marija A. Živković. "The Fuzzy–AHP Synthesis Model for Energy Security Assessment of the Serbian Natural Gas Sector" in Symmetry, MDPI AG (2020). https://doi.org/10.3390/sym12060908
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The Potential of Biomarkers to Distinguish Lower and Middle Miocene Lignites from the Coal-Mining District of Lusatia
... indicating no significant change in palaeclimate from Lower to Middle Miocene. Middle Miocene lignites are characterized by more pronounced variations of biomarker signatures than Lower Miocene samples, most probably due to the more pronounced fluctuation of water-level and/or palaeo-wildfires. The ...
... Cupressaceae and Phyllocladaceae, whereas cuparene and dehydroicetexane are specific for Cupressaceae (Nytoft et al., 2019). Slight input of aquatic macrophytes and ferns is also evident. The degrees of aromatization of diterpenoids and non-hopanoid pentacyclic triterpenoids (Stojanović and Životić ...
... greater contribution of angiosperms. The contents of C27 and C29 n-alkanes in relation to C31 and C33 homologues imply similar impact of forested and reed-mire vegetation. The presence of tricyclic (abietane, pimarane, isopimarane) and tetracyclic (phyllocladane, bayerane, kaurane) diterpenoids ...I. Kojic, J. Kus, D. Zivotic, K. Stojanovic. "The Potential of Biomarkers to Distinguish Lower and Middle Miocene Lignites from the Coal-Mining District of Lusatia" in 30th International Meeting on Organic Geochemistry (IMOG 2021), European Association of Geoscientists & Engineers (2021). https://doi.org/10.3997/2214-4609.202134092
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Geochemical characterization of sediments from the archaeological site Vinča – Belo Brdo, Serbia
Gorica Veselinović, Dragana Životić, Kristina Penezić, Milica Kašanin-Grubin, Nevenka Mijatović, Jovana Malbašić, Aleksandra Šajnović (2020)Gorica Veselinović, Dragana Životić, Kristina Penezić, Milica Kašanin-Grubin, Nevenka Mijatović, Jovana Malbašić, Aleksandra Šajnović. "Geochemical characterization of sediments from the archaeological site Vinča – Belo Brdo, Serbia" in CATENA, Elsevier BV (2020). https://doi.org/10.1016/j.catena.2020.104914
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... could be caused by the change from the glassy to the rubbery state of the steric stabilizers (polysorbate 80 and/or poloxamer 407). In this case, the nanoparticles would become mobile and could form solid aggregates. This process is favored at higher storage temperatures and in the presence of ...
... stability during storage, and drug nanocrystals are usually considered very stable if their redispersibility does not change significantly during storage (Beirowski et al., 2011). Since parenteral formulations are in focus, the dispersions should be redispersed rapidly and maintain nanometer particle ...
... detected by XRPD due to its low concentration and low intensity of diffraction peaks when it is in nanocrystalline form. The crystal structure of DK-I-56-1 in nano- crystalline formulation was confirmed in Mitrović et al. (2020), and would probably not change during lyophilization. The main disadvantage ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557