Претрага
145 items
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Hydrogeochemical distribution of Ca and Mg in groundwater in Serbia
Petar Papić, Jovana Milosavljević, Marina Ćuk, Rastko Petrović . "Hydrogeochemical distribution of Ca and Mg in groundwater in Serbia" in Groundwater: Occurrence and Significance for Human Health, CRC Press, Balkema - Taylor & Francis Group (2014)
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... Scientific, Wal- tham, MA, USA) FT-IR spectrometer equipped with a single reflection ATR system (Smart iTR, Thermo Scientific, USA) with diamond plate and ZnSe lens. Spectra were recorded in the range of 4000 cm ! to 660 cm ! with a resolution of 0.5 cm !. 3. Results and discussion 3.1. Preliminary ...
... polarized light microscopy (PLM). It was performed using Carl Zeiss ApoTome Imager Z1 microscope (Zeiss, Germany) with crossed polarizers and 4 X-plate. Photomicrographs were taken under 400 x magnification with the digital camera and processed with the appropriate software. 2.9. Fourier transform ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557
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A hundred years of Milutin Milanković's climate change theory - geological implications
Dejan Radivojević (2020)Миланковићева теорија циклуса објављена пре сто година је најважнија теорија у наукама које проучавају климу и имала је велики утицај на дисциплине које се баве Земљом. Ипак, његов рад је чекао више од педесет година да би добио потврду. Може се рећи да Миланковићев рад највећи утицај на геологију има у изради астрономске временске скале, подршци хипотези континенталног дрифта и палеоклиматологији. Добри резултати примене астрономске временске скале на неогене седименте иницирали су примену ове методе у мезозојским и у последње ...циклостратиграфија, астономска временска скала, геолошка временска скала, климатске промене, континентални дрифт... greenhouse gases in the geological past (e.g. during ordovician Period the amount of Co2 was 10–18 times higher than today) (PoUSSART et al., 1999). The plate tectonics regimes were more intensive during the greenhouse periods when volcanic activity and increased carbon dioxide release caused warming of the ...Dejan Radivojević. "A hundred years of Milutin Milanković's climate change theory - geological implications" in Geološki anali Balkanskoga Poluostrva, Univerzitet u Beogradu, Rudarsko geološki fakultet (2020). https://doi.org/10.2298/GABP201125011R
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Primena metoda podzemnog otkopavanja sa očuvanjem površine terena
Uroš Mirković (2024)Tema ovog diplomskog rada je primena metoda podzemnog otkopavanja sa očuvanjem površine terena, sa posebnim osvrtom na metodu otkopavanja uz zasipavanje pasta zasipima. Ova metoda omogućava efikasan eksploatacioni proces u podzemnim rudnicima, uz minimalne uticaje na površinu, čime se smanjuju deformacije i sleganja terena iznad eksploatacionih radova. Pasta zasipi, koji se sastoje od mešavine jalovine, vode i cementa, koriste se za popunjavanje ispražnjenih prostorija nakon otkopavanja, čime se obezbeđuje stabilnost okolnih stena i smanjuje rizik od urušavanja. Ovaj rad ...... prosečna bruto plata radnika od 1.000USD mesečno. Za 610, bruto plata iznosi 610.000 USD mesečno. Troškovi radne snage po toni rude iznose: 610.000 USD : 208.333 t = 2,93 USD/t. 60 Troškovi radne snage na pripremi rude: Za obračun zarada radnika uzima se prosečna bruto plata radnika 1.000 ...
... 000 t/god. Vek eksploatacije 25 godina Broj zaposlenih radnika na otkopavanju 610 Broj zaposlenih radnika na pripremi rude 280 Bruto prosečna plata mesečno 1.000 USD Cena bakra u katodi 5.500 USD/t Cena zlata 40.000 USD/kg Cena srebra 600 USD/kg Troškovi metalurške prerade bakra 600 USD/t ...
... 000 USD mesečno. Za 280 radnika, bruto plata iznosi 280.000 USD mesečno. Troškovi radne snage po toni rude iznose: 280.000 USD : 208.333 t = 1,34 USD/t Ukupni troškovi radne snage Ukupni troškovi za angažovanje radne snage iznosiće 890.000 USD. To znači da će troškovi radne snage po toni rude ...Uroš Mirković . Primena metoda podzemnog otkopavanja sa očuvanjem površine terena, 2024
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Anisotropic grossular–andradite garnets: Evidence of two stage skarn evolution from Rudnik, Central Serbia
This paper presents LA-ICP-MS data for garnets from the Rudnik skarn deposit (Serbia), which range from Grs45–58Adr40–52Alm2–3 in the core and Adr70–97Grs2–29Sps1 in the rim displaying anisotropy and zoning. In spite of wide compositional variations the garnets near the end-member of andradite (Adr > 90) are generally isotropic. Fe-rich rims exhibit LREE depletion and flat HREE pattern with weak negative Eu anomaly, including higher As and W contents. On the other side, the Fe-poorer core shows flat REE pattern ...... 1017/S0885715619000897 Ustaszewski K., Kounov A., Schmid S., Schaltegger U., Krenn E., Frank W. & Fügenschuh B. 2010: Evolution of the Adria-Europe plate boundary in the northern Dinarides: From continent-conti- nent collision to back-arc extension. Tectonics 29, 1–34. https:// doi.org/10.1029/2010TC002668 ...Bojan Kostić, Danica Srećković-Batoćanin, Petyo Filipov, Pavle Tančić, Kristijan Sokol. "Anisotropic grossular–andradite garnets: Evidence of two stage skarn evolution from Rudnik, Central Serbia" in Geologica Carpathica, Central Library of the Slovak Academy of Sciences (2021). https://doi.org/10.31577/GeolCarp.72.1.2
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Insights into dike nucleation and eruption dynamics from high-resolution seismic imaging of magmatic system at the East Pacific Rise
Milena Marjanović, Suzanne M. Carbotte, Alexandre Stopin, Satish C. Singh, René-Édouard Plessix, Miloš Marjanović, Mladen R. Nedimović, Juan Pablo Canales, Hélène D. Carton, John C. Mutter, Javier Escartín (2023)Milena Marjanović, Suzanne M. Carbotte, Alexandre Stopin, Satish C. Singh, René-Édouard Plessix, Miloš Marjanović, Mladen R. Nedimović, Juan Pablo Canales, Hélène D. Carton, John C. Mutter, Javier Escartín. "Insights into dike nucleation and eruption dynamics from high-resolution seismic imaging of magmatic system at the East Pacific Rise" in Science Advances, American Association for the Advancement of Science (AAAS) (2023). https://doi.org/10.1126/sciadv.adi2698
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Late and post-collisional tectonic evolution of the Adria-Europe suture in the Vardar Zone
The Vardar Zone is a product of the Triassic-Jurassic opening of the Neotethys, Jurassic obduction, Late Cretaceous/Paleogene consumption of the oceanic crust and continental collision. During the last process, the Eastern Vardar Zone was thrust over the Central and eventually both onto the Western Vardar Zone. The present paleomagnetic and structural study provided new results from the first two zones in the Belgrade area. The younger set of data, together with published ones from the third zone, provide firm ...Emő Márton, Marinko Toljić, Vesna Cvetkov. "Late and post-collisional tectonic evolution of the Adria-Europe suture in the Vardar Zone" in Journal of Geodynamics, Elsevier BV (2022). https://doi.org/10.1016/j.jog.2021.101880
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Multiple-Criteria Decision-Making in Mine Development Planning
Sanja Bajić (2023)The Borska Reka ore deposit is an experimental location where developed methodologies have been applied. It is the largest ore body within the Bor mining complex, which has been the subject of numerous studies and analyses for more than three decades. The paper focuses on the application of FAHP and the VIKOR method to address ranking of alternatives and select the optimal mining method by means of fuzzy multicriteria optimization.Sanja Bajić. "Multiple-Criteria Decision-Making in Mine Development Planning" in Proceedings of the 5th International Underground Excavations Symposium, 5-6-7 June 2023, Istanbul, Topkapi : Dinç Ofset Mat. Rek. San. ve Tic. Ltd. Şti. (2023)
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Geološko-geofizički model dela Timočkog magmatskog kompleksa
Snežana M. Ignjatović (2014-06-30)Timočki magmatski kompleks (TMK) u geotektonskom smislu pripada KarpatoBalkanidimaistočne Srbije, koji su deo Tekijsko-Dakijske jedinice. TMK je nastaotokom kontinuirane vulkanske aktivnosti, koja je trajala oko deset miliona godina iodvijala se generalno u tri faze (Zimmerman et al., 2008, Kolb et al., 2013, Banješević,2006). Pomeranje vulkanskog fronta je išlo od istoka ka zapadu (von Quadt et al., 2002,2003, 2007). Ovaj kompleks pripada tetijskom evroazijskom metalogenetskom pojasu usvetu poznat po ležištima bakra i zlata (Janković, 1990).U doktorskoj disertaciji su prikazani rezultati ...Timočki magmatski kompleks, aeromagnetska istraživanja, gravimetrijskaistraživanja, 2D geološko-geofizički model, Valja Strž, magmatsko telo... 37–47. Janković, S., 1977. Major alpine ore deposits and metallogenic units in the northeastern Mediterranean and concepts of plate tectonics. In:"Metallogeny and plate tectonics in the northeastern Mediterranean". Fac. Minin. Geol. Belgrad Univ. (edit.), 105- 171. Geološko-geofizički model ...
... Model of the Bor Deposit. Plate tectonic aspects of Alpine metallogeny in the Carpatho-Balkan region, 3rd Ann. Meeting, Athens, 11. Janković, S., 1996. Comparation between Metallogeny of Serbo- Macedonian Metallogenic Province and the Bor-Srednegorie Zone. In: ”Plate tectonic of the Alpine Metallogeny ...Snežana M. Ignjatović. "Geološko-geofizički model dela Timočkog magmatskog kompleksa" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2014-06-30)
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Using Lexical Resources for Irony and Sarcasm Classification
The paper presents a language dependent model for classification of statements into ironic and non-ironic. The model uses various language resources: morphological dictionaries, sentiment lexicon, lexicon of markers and a WordNet based ontology. This approach uses various features: antonymous pairs obtained using the reasoning rules over the Serbian WordNet ontology (R), antonymous pairs in which one member has positive sentiment polarity (PPR), polarity of positive sentiment words (PSP), ordered sequence of sentiment tags (OSA), Part-of-Speech tags of words (POS) ...... sarcastic tweet, like in the following example: Sreća pa zimus neće biti uglja, gasa, struje i ogreva jer sa ovim smanjenjem ne bi ni moglo da se plati! (sreća - žalost) ‘Fortunately this winter there will be no coal, gas, electricity or fuel, because with this pay cut it would be impossible to pay ...Miljana Mladenović, Cvetana Krstev, Jelena Mitrović, Ranka Stanković. "Using Lexical Resources for Irony and Sarcasm Classification" in Proceedings of the 8th Balkan Conference in Informatics (BCI '17), New York, NY, USA, : ACM (2017). https://doi.org/
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Bridging Computational Lexicography and Corpus Linguistics: A Query Extension for OntoLex-FrAC
OntoLex, dominantni standard zajednice za mašinski čitljive leksičke resurse u kontekstu RDF-a, Linked Data i tehnologija Semantičkog veba, trenutno se proširuje sa posebnim modulom za Frekvencije, Primere i Informacije zasnovane na Korpusu (OntoLex-FrAC). Predlažemo novi komponent za OntoLex-FrAC, koji se bavi inkorporacijom korpusnih upita za (a) povezivanje rečnika sa korpusnim mašinama, (b) omogućavanje RDF baziranih web servisa da dinamički razmenjuju korpusne upite i podatke odgovora, i (c) korišćenje konvencionalnih upitačkih jezika za formalizaciju unutrašnje strukture kolokacija, skica reči i ...standardizacija, digitalna leksikografija, OntoLex, upiti korpusa, povezani podaci, Lingvistički povezani otvoreni podaciChristian Chiarcos, Ranka Stanković, Maxim Ionov, Gilles Sérasset. "Bridging Computational Lexicography and Corpus Linguistics: A Query Extension for OntoLex-FrAC" in Proceedings of the 2024 Joint International Conference on Computational Linguistics, Language Resources and Evaluation (LREC-COLING 2024), Turin, 20-25 May 2024, LREC (2024)
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Tektonska evolucija ugljevičkog basena (Bosna i Hercegovina)
Slobodan Dragić (2024)U radu je prezentovana šira slika tektonske evolucije ugljevičkog basena, kao i Dinarida uopšte. Prikazani su litostratigrafski odnosi istraživanog područja, kao i kratak pregled tektonskih jedinica koje se nalaze u domenu basena. Najveća pažnja posvećena je kinematskoj analizi rasjednih struktura i interpretaciji podataka u svjetlu tektonske evolucije basena. Ugljevički basen zapunjen je oligocensko-miocenskim sedimentima, a njegovu osnovu grade paleozojsko-mezozojske formacije. Najstarije tvorevine na ovom području su permski sedimenti. Trijaski i kredni deponati, uglavnom krečnjaci, reprezent su tvorevina ...... MegaUnit biha ač Bisdaf kk dashed white lines: oulines of tectonic blocks" ma r aoagondes) B Dacia Moga-Unit pls + = · Outer perimeter Adriatic Plate inclućing E 29eriopaonik ts sheet is imbficated thrust sheels [Z TazaMoga-Unt Slika 12. Regionalni tektonski položaj istraživanog područja (de Leeuw ...
... Alps and Dinarides Ophioltes, oceanic accrebonary prisms Plemont-Liguria, Vahic, Inacovce-Kriscevo, Dalmatian Zone |2 Undeformed part of hhe Adriatic plato – [BMl Szolnok, a MVRa, Westem Varđar Ophiolitic Unit [Z Budva-Cukali Zone 73 Westem Imbricated Margin of Adria |__J (incl. Meliata-Makac & Mirdita ...Slobodan Dragić. Tektonska evolucija ugljevičkog basena (Bosna i Hercegovina), 2024
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Demise of the Wetterstein Carbonate Platform and onset of the Dachstein Carbonate Platform recorded in deep-water successions of the East Bosnian-Durmitor megaunit (Pliješevina, northern Montenegro, Dinarides)
Milica Mrdak, Eva Wagerer, Milan Sudar, Nevenka Djerić, Martin Đaković, Hans-Jürgen Gawlick. "Demise of the Wetterstein Carbonate Platform and onset of the Dachstein Carbonate Platform recorded in deep-water successions of the East Bosnian-Durmitor megaunit (Pliješevina, northern Montenegro, Dinarides)" in Geologica Carpathica, Central Library of the Slovak Academy of Sciences (2024). https://doi.org/10.31577/GeolCarp.2023.26
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Design of a sucker rod pumping system
Ana Ponoćko (2024)For a long time in the history of oil production, sucker rod pumps have been the first and in many cases the only choice when it comes to mechanical extraction methods. Proper selection of each individual element of the system enables optimization, which entails benefits in the form of increased efficiency and reduced costs. The first part of the paper presents the underground and surface equipment of the rod pump and describes the operation of the entire system. The ...... BARaA 6.5. Figure Well XX-1 in Prosper |_PVT Data T Oil Gravity 920 Kg/m3 Polished Rod Power 0.32914 - |kw (Gas Gravity 0.687 sp. gravity Name Plate Power\ 0.44828 w Water Salinity 6221.83____ppm WorkDone ByPump|9050.19 — |N _E pre== Work Done By Polished Rod| 33699.1 — |N Gas Oil Ratio, 25 ...Ana Ponoćko. Design of a sucker rod pumping system, 2024
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Tectonic evolution of the Circum-Moesian orocline of the Carpatho-Balkanides: Paleomagnetic constraints
Emő Márton, Vesna Cvetkov, Miodrag Banješević, Gábor Imre, Aleksandar Pačevski. "Tectonic evolution of the Circum-Moesian orocline of the Carpatho-Balkanides: Paleomagnetic constraints" in Journal of Geodynamics, Elsevier BV (2024). https://doi.org/10.1016/j.jog.2024.102058
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Regionalno-geološke karakteristike miocenskih sedimenata na prostoru severnog Banata
Dejan N. Radivojević (2014-12-30)Predmet doktorske disertacije predstavljalo je rešavanje strukturno‐stratigrafskihodnosa miocenskih sedimenata na prostoru severnog Banata. U cilju regionalnogsagledavanja, korišćeni su svi raspoloživi geofizički i geološki podaci sa širegistražnog područja, odnosno iz celog Panonskog basena i susednog orogena. Osimklasičnih metoda primenjene su i savremene metode seizmostratigrafije,tektonostratigrafije i riftne sekvencione stratigrafije. Primenjene metode omogućilesu izradu modela progradacije ivice šelfa za ceo Panonski basen, modela uzajamnihveza između basena i geodinamičkog modela jugoistočnog oboda basena.Jezero Panon je većim delom zapunjeno prilivom sedimenata paleo‐Dunavom saseverozapada, odnosno ...Centralni Paratetis, Panonski basen, miocen, jezero Panon,seizmostratigrafija, sekvenciona stratigrafija, paleogeografija, geodinamika... tectonic evolution of the Intra‐Carpathian area: a review, Acta Vulcanologica, v. 7, p. 1–13. Csontos, L., and A. Vörös, 2004, Mesozoic plate tectonic reconstruction of the Carpathian region, Palaeogeogr., Palaeocl., Palaeoecol., v. 210(1), p. 1–56, doi:10.1016/j.palaeo.2004.02.033 ...
... Ustaszewski, K., A. Kounov, S. M. Schmid, U. Schaltegger, E. Krenn, W. Frank, and B. Fügenschuh, 2010, Evolution of the Adria‐Europe plate boundary in the northern Dinarides: From continent‐continent collision to back‐arc extension, Tectonics, v. 29, TC6017, doi:10.1029/2010TC002668 ...
... Palaeoclimatology, Palaeoecology, 297, 54–69. Vörös, A., 1977, Provinciality of the Mediterranean Lower Jurassic brachiopod fauna: causes and plate‐tectonic implications, Paleogeography Paleoclimatology Paleoecology, v. 21, p. 1–16. Vrabec, M., and L. Fodor, 2005, Late Cenozoic tectonics ...Dejan N. Radivojević. "Regionalno-geološke karakteristike miocenskih sedimenata na prostoru severnog Banata" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2014-12-30)
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Sustainable Modularity Approach to Facilities Development Based on Geothermal Energy Potential
The study presented in this paper assessed the multidisciplinary approach of geothermal potential in the area of the most southeastern part of the Pannonian basin, focused on resources utilization. This study aims to present a method for the cascade use of geothermal energy as a source of thermal energy for space heating and cooling and as a resource for balneological purposes. Two particular sites were selected—one in a natural environment; the other within a small settlement. Geothermal resources come ...геотермална енергија, Панонски басен, геотермална каскада, енергетска ефикасност, бањски центри, балнеологија, биоклиматска архитектура, стратегије пасивног дизајнирања, модуларни објекти... Available thermal power from the geothermal resource at B.V. Selo (VS-2/H) site is calculated for the following scenario: • passive geothermal system with plate heat exchanger • covering peak-load demands • first cascade stage (temperature reduction for heating) • second cascade stage (for balneological purposes ...Nataša Čuković-Ignjatović, Ana Vranješ, Dušan Ignjatović, Dejan Milenić, Olivera Krunić. "Sustainable Modularity Approach to Facilities Development Based on Geothermal Energy Potential" in Applied Sciences-Basel, МDPI (2021). https://doi.org/10.3390/app11062691
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Analiza mogućnosti primene tehnologije hvatanja i skladištenja ugljenika (CO2) na objektima Nis-A
Isidora Veljanoski (2024)U ovom radu opisana je primena CCUS tehnologija u kompaniji NIS i na koji način treba da se optimizuje da bi projekat bio rentabilan.U prvom i drugom poglavlju opisani su energetski trendovi i tranzicije, razvojni mehanizmi za regulisanje emisije gasova staklene baste i o ugljen-dioksidu kao hemijskom jedinjenju i šta je to CCUS.U trećem, četvrtom i petom poglavlju je detaljnije opisano izdvajanje, hvatanje, transport i skladištenje ugljen-dioksida.Šesto poglavlje i sedmo poglavlje obuhvataju rešenja za razvoj i realizaciju CCUS projekata ...energetski trendovi, ugljen-dioksid, CCUS, izdvajanje, hvatanje, transport i skladištenje CO2, ležište, ekonomija projekta... OPEX (Operating Expenditures) su operativni troškovi koje kompanija ima tokom svakodnevnog rada. To su troškovi neophodni za održavanje opreme, plate zaposlenih... 47 8.2 „Ekonomski model potencijalnog projekta Kako bi se donela odluka o potencijalnom realizaciji projekta hvatanja i skladištenja ...Isidora Veljanoski. Analiza mogućnosti primene tehnologije hvatanja i skladištenja ugljenika (CO2) na objektima Nis-A, 2024
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Geotechnical conditions of “Debelo brdo” tunnel construction on the highway E-80: Nis-Merdare-Pristina (“Peace Highway”)
The construction of the highway E-80 has begun in Serbia, which will represent the traffic hub of the Western Balkans and will be part of the main regional transport network of Southeast Europe. Its total length through Serbia is 77 km, and one part of the route is designed through a typical plain terrain, while a larger part of the route passes through hilly terrain. The construction of the tunnel “Debelo brdo” is planned partly in an open cut ...Dragoslav Rakić, Irena Basarić Ikodinović, Radojica Lapčević, Dragan Lukić. "Geotechnical conditions of “Debelo brdo” tunnel construction on the highway E-80: Nis-Merdare-Pristina (“Peace Highway”)" in Proceedings of the XVIII ECSMGE 2024 geotechnical engineering challenges to meet current and emerging needs of society, Lisbon, 26-30 August 2024, CRC Press (2024). https://doi.org/10.1201/9781003431749-356
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Clockwise vertical-axis rotation in the West Vardar zone of Serbia: Tectonic implications
The Vardar-Tethyan mega-suture between the Eurasian and Adria (Gondwana) margins comprises remnants of oceanic lithosphere of Neotethys and distal parts of the adjacent continental margins including unconformable Late Cretaceous sedimentary cover and Cenozoic igneous rocks of post-obduction age. This study provides kinematic constraints for displacements and rotations affecting the Serbian part of the West Vardar and Jadar-Kopaonik units after the closure of the Neotethyan (= Sava) Ocean. The targets of the paleomagnetic research were Late Cretaceous sediments representing an ...... W. (2011). New Paleoce-Eocene paleomagnetic results from the foreland of the Southern Alps confirm decoupling of stable Adria from the African plate. Tectonophysics, 504, 89–99. Matenco, L., & Radivojević, D. (2012). On the formation and evolution of the Pannonian Basin: Constrains derived from ...Vesna Lesić, Emo Márton, Violeta Gajić, Dragana Jovanović, Vesna Cvetkov. "Clockwise vertical-axis rotation in the West Vardar zone of Serbia: Tectonic implications" in Swiss Journal of Geosciences, Basel : Springer International Publishing (2018). https://doi.org/10.1007/s00015-018-0321-8