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899 items
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Pleistocene rhinoceros from Bogovina Cave: the first report of Stephanorhinus hundsheimensis Toula, 1902 (Mammalia, Rhinocerotidae) from Serbia
Finds of Pleistocene rhinoceros are rare in Serbia, and only one species (the woolly rhinoceros Coelodonta antiquitatis Blumenbach, 1799) has been reported so far. The current paper presents the dental material of an extinct so-called Hundsheim rhinoceros, Stephanorhinus hundsheimensis Toula, 1902 from Bogovina Cave (East ern Serbia). Both the morphological and metric characteristics of the teeth are consis tent with the attribution to S. hundsheimensis. Unfortunately, the rhinoceros material originated from an uncertain geological context, so there is no ...... .org/10.1016/j.quascirev.2009.07.022 Ros-Montoya, S., Martínez-Navarro, B., Espigares, M.-P., Guerra-Merchán, A., García-Aguilar, J.M., Piñero, P., Rodríguez-Rueda, A., Agustí, J., Oms, O., and Palmqvist, P. 2017. A new Ruscinian site in Europe: Baza-1 (Baza basin, Andalusia, Spain). Comptes Rendus ...
... 0. Dokmanovic, P., Jemcov, I., Milanovic, S., and Hajdin, B. 2003. Hydrogeological risk factors of dam and reservoir construction-case example Bogovina. Materials and Geoenvironment, 50(1):105-108. Eisenmann, V., Alberdi, M.T., de Giuli, C., and Staesche, U. 1988. Methodology, p. 1-71. In Woodburne ...
... Transbaikalia, Russia. Asian Paleoprimatology, 5:61-98. Gentry, A.W. 1999. Fossil ruminants (Mammalia, Artiodactyla) from Westbury Cave, p. 139-174. In Andrews, P., Cook, J., Currant, A., and Stringer, C. (eds.), Westbury Cave: The Natural History Museum Excavations 1976-1984. Western Academic and ...Predrag Radović, Miloš Radonjić, Emmanuel Billia. "Pleistocene rhinoceros from Bogovina Cave: the first report of Stephanorhinus hundsheimensis Toula, 1902 (Mammalia, Rhinocerotidae) from Serbia" in Palaeontologia Electronica, Coquina Press (2020). https://doi.org/10.26879/985
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Semi-Automatic Extraction of Multiword Terms from Domain-Specific Corpora
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<p>The server encountered an internal error and was unable to complete your request. Either the server is overloaded or there is an error in the application.p> ...Vesna Pajić, Staša Vujičić Stanković, Ranka Stanković, Miloš Pajić. "Semi-Automatic Extraction of Multiword Terms from Domain-Specific Corpora" in The Electronic Library 36 no. 3, Emerald Publishing Limited (2018): 550-567. https://doi.org/10.1108/EL-06-2017-0128
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Palinomorfe sa lokaliteta Gostuška reka (Stara planina)
Ivan Rutović (2024)U radu su prikazani rezultati palinološkog istraživanja permsko-trijaskih sedimenata sa lokaliteta Gostuška reka. Palinološki kompleksi su detaljno analizirani, što je omogućilo morfološku, taksonomsku i paleoekološku identifikaciju palinomorfi. Istraživanje je pokazalo prisustvo velikog broja spora i polena golosemenica, dok je polen skrivenosemenica zastupljen u manjem procentu. Na osnovu paleoekoloških analiza, zaključeno je da je tokom formiranja sedimenata na lokalitetu vladala aridna klima, sa povremenim vlažnim fazama koje su omogućavale razvoj močvarne vegetacije.... Krstić B., Bogdanović P., Jadranin D., Milenković P., Milošaković R., Fotić P., i Jovanović LJ., 1969: Osnovna geološka karta SFRJ – Pirot 1:100 000. Beograd: Zavod za geološke i geofizička istraživanja. 4Anđelković J., Krstić B., Bogdanović P., Jadranin D., Milenković P., Milošaković RM., Urošević ...
... SI. G. 1953 Sfenozonatriletes argenteaeformis Bolkhovitina p. 51, pl. 7, fig. 9. 1997 Uvaesporites argenteaeformis (Bolkh.) Schulz – Adloff & Doubinger, tab. 1, sl. 15 2000 Uvaesporites argenteaeformis (Bolchovitina) Schulz; Gao et al. p. 222, pl. 8, fig. 16. 2001 Uvaesporites argenteaeformis ...
... anisian of the transdanubian central range (Hungery) and the Vicentinian Alps (Htaly). — Unpubl. Ph. D. thesis, State Univ. Utrecht, 95 p. 34 Cassinis, G., di Stefano, P., Massari, F., Neri, C. & Venturini, C. 2000: Permian of south Europe and its interregional correlation. (In: Permian-Triassic Evolution ...Ivan Rutović. Palinomorfe sa lokaliteta Gostuška reka (Stara planina), 2024
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Rock slope stability analysis under Hoek–Brown failure criterion with different flow rules
The stability analysis of homogeneous rock slope following the Hoek–Brown failure criterion under the hypothesis of different flow rules is performed based on limit equilibrium and finite element methods. The applied failure criterion is the generalized Hoek–Brown that can be introduced as a shear/normal function in analysis applying different flow rules. The results are compared with those obtained by the application of equivalent shear strength parameters of the Mohr–Coulomb criterion, considering that this is still the most widely used ...Kružna klizna površ, Huk-Braunov kriterijum loma, Kriterijum popuštanja, Smičuća/normalna funkcija, Nivo napona, Verovatnoća i parametarska analizaSvetlana Melentijević, Zoran Berisavljević, Dušan Berisavljević, Claudio Olalla Marañón . "Rock slope stability analysis under Hoek–Brown failure criterion with different flow rules" in Bulletin of Engineering Geology and the Environment , Springer (2024). https://doi.org/10.1007/s10064-024-03667-0
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Callovian (Middle Jurassic) Sphriganaria (Brachiopoda) from the Jordan Valley (Middle East)
Howard R. Feldman, Barbara V. Radulović, Fayez Ahmad. "Callovian (Middle Jurassic) Sphriganaria (Brachiopoda) from the Jordan Valley (Middle East)" in Historical Biology (2023). https://doi.org/10.1080/08912963.2022.2122823
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Development of Open Educational Resources (OER) for Natural Language Processing
In this paper we present the development of an online course at the edX BAEKTEL platform named “Lexical Recognition in the Natural Language Processing (NLP)”. It is based on the course of the same name for PhD studies at the University of Belgrade, Faculty of Philology. There are not many courses in Computational Linguistics (CL) on OER platforms, and there is none in Serbian either for CL or NLP. We have developed this course in order to improve this ...... Innovation and Entrepreneurship: Connecting the Knowledge Dots, J. Spender, G. Schiuma, and V. Albino, Editors. 2015: Bary, Italy. p. 1801-1812. [2] Jackson, P. and I. Moulinier, Natural Language Processing for Online Applications: Text Retrieval, Extraction and Categorization. 2002: John Benjamins ...
... 40(2): p. 152-162. [9] Krstev, C., Information Science Curriculum at the Undergraduate Studies of Library and Information Science, in Skup bibliotekara balkanskih zemalja: Saradnja obrazovanje kvalitet, A. Vraneš and L. Marković, Editors. 2002, Narodna biblioteka Srbije: Belgrade. p. 117-122 ...
... Linguistics, M. Gross and D. Perrin, Editors. 1989, Springer Berlin Heidelberg. p. 34-50. [13] Vitas, D. and C. Krstev, Processing of Corpora of Serbian Using Electronic Dictionaries. Prace Filologiczne, 2012. LXIII: p. 279-292. [14] Utvić, M., Izgradnja referentnog korpusa savremenog srpskog ...Cvetana Krstev, Biljana Lazić, Ranka Stanković, Giovanni Schiuma, Miladin Kotorčević. "Development of Open Educational Resources (OER) for Natural Language Processing" in The Sixth International Conference on e-Learning (eLearning-2015), September 2015, Belgrade, Serbia, Belgrade : Belgrade Metropolitan Univesity (2015)
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Late Triassic radiolarians from the Grivska formation, internal Dinarides, SW Serbia
Paleontology, Stratigraphy, Economic Geology, Geochemistry and Petrology, Geology, Geophysics, Geotechnical Engineering and Engineering Geology... 2003) and Zone Capnodoce Eptingiidae ? gen. et sp. indet. R crystallina of Eastern Russia .. Palaeosaturnalis sp. |-- J ” | m M | P | P | m P | = P | G O | P | G O | Q m | > (BRAciN, 2000). Praehexasaturnalis tenuispinosus (DONOFRIO & MOSTLER) Paronaella sp. Triassocrucella sp. cf. T. ...
... NEWPoORT, 1972 and DUMITRICA, 1970, residues were washed by water, then cleaned by hot water (10—15 g) with 0.5 g tetra- sodium pyrophosphate (Na„,P.,O,) to remove clay par- ticles. Radiolarians were picked from dried residues under light binocular microscope LOMO-MBS-10, Fig. 2. Limestones oftthe ...
... series: Emile Argand Conference - 13th Workshop on Alpine Ge- ological Studies, September 7th-18th 2017, Zlatibor Mts. (Serbia), Abstract volume, p. 22, University of Belgrade, Faculty of Mining and Geology, Belgrade. BRAGIN, N., BRAGINA, L., GERZINA SPAJIĆ, N., DJERIĆ, N. & SCHMID, S. 2018 ...Nikita Bragin, Liubov Bragina, Nevenka Đerić, Nataša Gerzina-Spajić. "Late Triassic radiolarians from the Grivska formation, internal Dinarides, SW Serbia" in Geološki anali Balkanskoga poluostrva (2019). https://doi.org/10.2298/GABP1901017B
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Primena AHP и WoEmetode u proceni podložnosti terena na kliženje za područje opštine Krupanj
Biljana Abolmasov, Jelka Krušić, Katarina Andrejev, Miloš Marjanović, Ranka Stanković, Uroš Đurić (2017)... WoE Osetljivost TPR=TP/P=TP/(TP + FN) 0,718727 0,706291 Specifičnost SPC=TN/N=TN/(FP + TN) 0,556080 0,606018 Stopa lažno pozitivnih (FPR) FPR=FP/N=FP/(FP + TN) 0,443919 0,393981 Stopa lažno negativnih (FNR) FNR=FN/P =FN(TP + FN) 0,281272 0,293708 Tačnost ACC=(TP + TN)/(P + N) 0,557258 0,606744 ...
... rasprostranjenje na istraž- nom području. Razlikuju se dva superpoziciona paketa: srednji perm (P 2 ) predstavljen terigenim sedimentima – kvarcnim peščarima i peskovito – glinovitim škriljcima i mlađim (P 3 ) predstavljenim slojevitim krečnjacima, glin- cima i peščarima. Sedimenti mezozoika su p ...
... negativnih qij “dokaza“, a na osnovu njihovih težinskih faktora. Težina dokaza (Weight of Evidence) – wij se računa na sledeći način (jednačina 2): W p q ij ij ij = ln (2) gde je: pij – broj pozitivnih “dokaza“za klasu j, i-tog parametra, podeljen ukupnim brojem pozitivnih ...Biljana Abolmasov, Jelka Krušić, Katarina Andrejev, Miloš Marjanović, Ranka Stanković, Uroš Đurić . "Primena AHP и WoEmetode u proceni podložnosti terena na kliženje za područje opštine Krupanj" in Izgradnja, Beograd : Udruženje inženjera građevinarstva, geotehnike, arhitekture i urbanista Izgradnja (2017): 239-246
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The Rift Sequence Stratigraphy of the Itebej Field (Pannonian Basin, Serbia)
... Central Paratethys, Itebej field, rift sequence stratigraphy, reef sediments, petroleum system References Tari, G., P. Dovenyi, I. Dunkl, F. Horvath, L. Lenkey, M. Ștefănescu, P. Szafian, and T. Toth, 1999. Lithospheric structure of the Pannonian basin derived from seismic, gravity and geothermal ...
... extension within the Alpine Orogen, edited by B. Durand, L. Jolivet, F. Horvath and M. Serrane, pp. 215-250, Geol. Soc. London Spec. Publ. 156. ABSTRACTS P - 139 ...Saša Ivanišević, Jelena Radišić, Ivana Isić, Dejan Radivojević. "The Rift Sequence Stratigraphy of the Itebej Field (Pannonian Basin, Serbia)" in AAPG Vienna, Paratethys petroleum systems between Central Europe and the Caspian Region, Vienna, 26-27 mart, 2019, AAPG (2019)
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Neogena i kvartarna herpetofauna (Anura i Squamata) Srbije : doktorska disertacija
Dragana D. Đurić (2019)U radu je prvi put opisan deo herpetofaune (Anura i Squamata) iz neogenih i kvartarnih lokaliteta Srbije. Obrađeni su lokaliteti Sibnica, Prebreza, Lazarevc, Vračević i Riđake, neogene starosti. Lokaliteti kvartarne starosti su pećine Mala i Velika Balanica, Pešturina, Hadži Prodanova, Baranica, Vrelska pećina i sedimentne ispune fisura u kamenolomima Venčac i Beočin. U radu je prikazana je taksonomska analiza herpetoloških ostataka. Pored taksonomske analize fosilnog materijala dat je kratak geografsko-geološki opis proučavanih lokaliteta, osnovne osteološke karakteristike anura i skvamata ...... zastupljen je sa dve vrste – P. laurilardi i P. pannonicus, koji se za razliku od savremenog P. apodus sreću u delimično i izrazito vlažnim staništima obraslim šumom (Klembara et al. 2010). Herpeto–asocijacija iz Lazarevca, koju čine Agama s.l., Pseudopus sp. P. cf. P. laurillardi, Ranidae, nešto ...
... (Biton et al. 2016). Izumrle vrste Pseudopus-a, P. laurillardi i P. pannonicus, zajedno sa savremenom vrstom Pseudopus apodus, ilustruju povlačenje ovog roda od zapada Evrope ka jugoistoku Evroazije (Klembara & Rummel 2018). Pseudopus laurillardi i P. Pannonicus, za razliku od recentnog srodnika, ...
... aridizaciji prostora Srbije od miocena do danas. Od pet izumrlih taksona, četiri (Latonia gigantea, Palaeobatrachus sp., Pseudopus cf. P. laurillardi i P. cf. P. pannonicus) su iz miocenskih lokaliteta sa toplom i vlažnom klimom. Izumrla Zamenis paralongissimus prvi put je u Srbiji identifikovana u ...Dragana D. Đurić. Neogena i kvartarna herpetofauna (Anura i Squamata) Srbije : doktorska disertacija, Beograd : Rudarsko-geološki fakultet, 2019
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Развој алгоритма процене ефеката ризика рада рударских машина на бази фази алгебре
Dejan V. Petrović (2014-12-30)Појава изненадних отказа елемената техничких система у рударству је свакодневна појава......500 Internal Server Error Internal Server Error
<p>The server encountered an internal error and was unable to complete your request. Either the server is overloaded or there is an error in the application.p> ...Dejan V. Petrović. "Развој алгоритма процене ефеката ризика рада рударских машина на бази фази алгебре" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2014-12-30)
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BEYOND 2020 - Geology explorations and open pit activities affectation in reclamation designing in Kolubara Coal Mines (KCM) Serbia, new considerations
Geology explorations in KCM runs from 1936. year up to these days and still ongoing. Results in >7,200 drill holes with ≈600,000 m of core drilling and gave lignite ore resources of > 4,1Bt, which 1,15Bt are excavated since 1986. of XIX up to early years of XXI century. For further mining operations in open pits stay 1,5Bt of lignite. Under waste heaps are ≈80 km2, additional 85 km2 should be filled. All of that masses/areas were, are ...Bojan Dimitrijević, Bogoljub Vučković, Radmila Gaćina. "BEYOND 2020 - Geology explorations and open pit activities affectation in reclamation designing in Kolubara Coal Mines (KCM) Serbia, new considerations" in 17th International Conference of the open and underwater mining of minerals, Sts. Constantine and Helena Resort, Varna, 18-22 September, Bulgaria, Sofia, Bulgaria : Scientific and Technical Union of Mining, Geology and Metallurgy, (2023)
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Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica
Nature and Landscape Conservation, Soil Science, Agronomy and Crop Science, Water Science and TechnologyNatalija Momirović, Ratko Kadović, Veljko Perović, Miloš Marjanović, Aleksandar Baumgertel. "Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica" in International Soil and Water Conservation Research, Elsevier BV (2019). https://doi.org/10.1016/j.iswcr.2018.12.004
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Анализа режима истицања карстног врела Горњи Душник (Сува планина)
Александар Танасковић (2024)Карстно врело Горњи Душник налази се у истоименом селу у југоисточној Србији, у општини Гаџин Хан. Врело је узлазног типа и дренира западне делове Суве планине.Каптирано је за потребе водоснабдевања Гаџиног Хана, као и села Горњи и Доњи Душник.Током 2023. и 2024. године спроведена су хидрогеолошка истраживања, са циљем дефинисања режима и биланса подземних вода врела Горњи Душник. У ту сврху, коришћени су подаци из два осматрачка периода.Прва осматрања режима истицања је вршио Геозавод, од 1.11.1977. до 31.01.1979. године.Затим су ...... Ba6yuiHvua Huui –= MN MN w O o w O _S1960 1970 2000 2010 _2020 __1960 _ 1970 _ 1980 1990 2000 2010 _ 2020 T i p o c e u H e T e M n e p a T y p e y ?C no c e 3 o H a M a rn o r o n M H a M a eTiponohe eJlero “ JeceH e 3WwMa e Tiponehe eJlero “ JeceH 3vMMa Cmage ...
... rnpowMeHa 3ajmxe BOJIĆ y CJIHBy 32 BDČMECHCKH HHTCPBAa:I At. JeynHauHHa BOJIHOT OgBmnaHca cJIHBa 3a BHIHCTOJIHIIM-H IIČpHojI r JtacH: P-(h-E)=0 OJIHOCHO P=h+E rne cy: P – CpeJIPe BHIHETOJIHIIH4 BpeJIHOCT IIpocCeuHHX CyMa IajlaBHHa Ha CJIHBy, h – CpeJIHe BHIHETOJIHIHIH4 BpeJIHOCT CJIOJa OTHIIaJa Ca ...
... IIpoceuHa BHITeroJuHHIMPa BpeJIHOCT cCJIOJa OTHIaJA 1000:·W h=-———— (mm) F MHcnapaaBbe E=P-h (mm) Cnenu()auHu orumaj o == 1/s/km? d-- ( ) IIpoceunu BHnrteroyJHpH Koe(bunujeHT oTHIaja h p P Beh Je peueHo Jta HMaMO JIBa OJiBOjeHa OcMaTpauka nepuojia, npBH op XI 1977. no I 1979. KaJja ...Александар Танасковић. Анализа режима истицања карстног врела Горњи Душник (Сува планина), 2024
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Equilibrium and kinetic studies of the reactions between [Ru(terpy)(bipy)Cl]Cl complex and biologically important N-donor ligands
Studije u oblasti antikancerogenih karakteristika jedinjenja rutenijuma(III/II) izazivaju veliku pažnju već nekoliko godina otkako su neka od njih kao što su KP1019 (indazolijum-tetrahloridobis(H-indazol)rutenat(III)) i NAMI-A (imidazolijum) -trans-tetrahlorido(dimetilsulfoksid)indazolerutenat(III)) dostigao nivo kliničkog ispitivanja. Kompleksi rutenijuma u reakciji sa molekulom DNK formiraju prvenstveno gvanin- i adenin-adukt, kao komplekse platine. Takođe, nekoliko studija ukazuje na veoma jake interakcije sa proteinima. Međutim, kompleksi Ru(III/II) pokazuju generalno manje toksične efekte od lekova platine(II).1 Proučavali smo kinetiku reakcija supstitucije kompleksa [Ru(terpi)(bipi)Cl]Cl sa biološki važnim ligandima: dimetilsulfoksidom, gvanozin-5’-monofosfatom, ...Aleksandar Mijatović, Biljana Petrović, Ratomir Jelić, Živadin Bugarčić. "Equilibrium and kinetic studies of the reactions between [Ru(terpy)(bipy)Cl]Cl complex and biologically important N-donor ligands" in EuroAnalysis 16 - Challenges in Modern Analytical Chemistry, Belgrade : Division of Analytical Chemistry of the Serbian Chemical Society (2011)
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Serbian Society of Geomorphologists
Dragana Đurić, Jelena Ćalić (2019)Dragana Đurić, Jelena Ćalić. "Serbian Society of Geomorphologists" in GeomorForum 2019: Landforms related to plains of Serbia and its neighboring area, Conference Programme and Abstracts, Beograd, 10-12. maj 2019, Serbian Society of Geomorphologists (2019)
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FTIR spectroscopic study оf S-мetolachlor сorption оn inorganic and organically modified montmorillonite from Bogovina
... s i s BOA A H || s|--38 8 P A g s - | „ihi š š - | || +NM a 3i af Š | 5 š [ IB || P || \8 ti o E \, 8 \ i 33 MA š šš ž B NaM EE “0 300 200 100 1500 1000 Wavenumber {cm ) Wavenumber {cm ') š 18p f) PTMA |j | |ž š \|E a E 13 i - PMV A | i n g"VA/B i g .| š P E Hi )s i . H | Š PONE ...
... r, V., Makreski, P..2012. NIR and MIR spectroscopic characteristics of hydrophilic and hydrophobic bentonite treated with sulphuric acid. Vib. Spectrosc., 58, 95-—103. DOI: 10.1016/J.vibspec.2011.11.002 Tomić, P.Z., Ašanin, P.D., Đurović-Pejčev, R., Đorđević, A., Makreski, P., 2015. Adsorption ...
... metolachlor in soil: effect of new organoclay formulations. Pestic. Sci., 55, 857— 864. DOI: 10.1002/(SICI)1096-9063(199908)55:8<857::AID-PS24>3.0.CO:2-P El-Nahhal, Y., Nir, S., Serban, C., Rabinovitz, O., Rubin, B., 2001. Organoclay formulation of acetochlor for reduced movementin soil. J. Agric. Food ...Lazar Kaluđerović, Zorica Tomić, Jelena Bogosavljević, Ljubomir Životić, Maja Milošević. "FTIR spectroscopic study оf S-мetolachlor сorption оn inorganic and organically modified montmorillonite from Bogovina" in Book of Proceedings / 3rd International and 15th National Congress Soils for Future Under Global Challenges, 21-24 September 2021 Sokobanja, Serbia , Belgrade : Serbian Society of Soil Science (2021)
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Evidence of Variscan and Alpine tectonics in the structural and thermochronological record of the central Serbo-Macedonian Massif (south-eastern Serbia)
... Jo oJenbs uvojA| a uonv|no|eo e p u posn sdojs Surinp poseo|o: 1y e JO 9861U9010d „ posvojor ı V e % OS< Ueds pue *0 G UUUJ SSO| Aq Joy}ip 1eU} Soyep ojqeusmSunsıp p[otX jeup sdoys Suneou snon8nuoo č< Jo o p uboul poyuSioA A *(neoyp{d o ...
... 18 0.0030. P 016 Fa = 330 i 0.0025 Š 0 Šou H q ŽNN 0.0 Š ol esnava.oam —— NN | lStaMa.gz a 052000 734Ma-2.01% WM:298.9+7.6Ma kitaod 270 MSWD?L 0.06 | -— MSWD3658 260 0.0005 ——p šš PaL_ _ _____ ii TEA — 240 0.02. 0.0000. — 0 o D O O O G 0 80 90 00 9 % O 4 O 6 70 85 80 100 0000 p&6o5 0607 0SGIO ...
... to authorized users. P< Milorad D. Antić m.antic('unibas.ch Institute for Geology and Palaeontology, University of Basel, 4056 Basel, Switzerland Faculty of Mining and Geology, University of Belgrade, Belgrade 11000, Serbia Section des Sciences de la Terre et de P Environnement, Universitć ...Milorad D. Antić, Alexandre Kounov, Branislav Trivić, Richard Spikings, Andreas Wetzel. "Evidence of Variscan and Alpine tectonics in the structural and thermochronological record of the central Serbo-Macedonian Massif (south-eastern Serbia)" in International Journal of Earth Sciences, Springer Science and Business Media LLC (2016). https://doi.org/10.1007/s00531-016-1380-6
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Insights into dike nucleation and eruption dynamics from high-resolution seismic imaging of magmatic system at the East Pacific Rise
Milena Marjanović, Suzanne M. Carbotte, Alexandre Stopin, Satish C. Singh, René-Édouard Plessix, Miloš Marjanović, Mladen R. Nedimović, Juan Pablo Canales, Hélène D. Carton, John C. Mutter, Javier Escartín (2023)Milena Marjanović, Suzanne M. Carbotte, Alexandre Stopin, Satish C. Singh, René-Édouard Plessix, Miloš Marjanović, Mladen R. Nedimović, Juan Pablo Canales, Hélène D. Carton, John C. Mutter, Javier Escartín. "Insights into dike nucleation and eruption dynamics from high-resolution seismic imaging of magmatic system at the East Pacific Rise" in Science Advances, American Association for the Advancement of Science (AAAS) (2023). https://doi.org/10.1126/sciadv.adi2698
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... nanosus- pensions decreased to the values similar to the ones in the corresponding suspensions (p = 0.563 and 0.965 for F5 vs. S5, and F6 vs. S6, respectively, Student t-test) except in the case of F9 (p < 0.01, Student t-test). In this formulation, the solubility of DK-I-60-3 in 0.1 M HCl was surprisingly ...
... fasted and fed state (p = 0.998 and 0.100 for Cmax and AUC, respectively, Student t-test). In investigated solid tissues, although average values of AUC seem to be different, even two times higher in the group of fed animals, statistically the differences were not significant (p = 0.933, 0.484, and 0 ...
... B.; Van den Mooter, G.; Augustijns, P. Top-down production of drug nanocrystals: Nanosuspension stabiliza- tion, miniaturization and transformation into solid products. Int. J. Pharm. 2008, 364, 64–75. [CrossRef] 16. Siewert, C.; Moog, R.; Alex, R.; Kretzer, P.; Rothenhäusler, B. Process and scaling ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188