Претрага
437 items
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... conducted after oral administration of nanocrystal formulation F5 and corresponding coarse suspension with the same qualitative and quan- titative content (S5) in fasted and fed state. In fasted group, food intake was restricted 10 h before and 4 h after formulation administration, while water was provided ...
... dispersions (F5, F6, and F8), the corresponding sus- pensions (S5, S6, and S8), as well as coarse DK-I-60-3 are shown in Figure 6a. The DK-I-60-3 content in nanocrystalline formulations F5, F6, and F8 was 93.79 ± 2.86%, 94.89 ± 1.36%, and 92.32 ± 2.99%, respectively, relative to the theoretical concentration ...
... Nanocrystal dispersions of DK-I-60-3 with small particle size and three months’ stability were prepared by the modified wet media milling technique. Content of DK-I-60-3 in developed dispersions close to theoretical values indicated no significant adsorption of DK-I-60-3 to milling beads, while XRPD proved ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals
Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić (2020)As the number of poorly soluble drugs is increasing, nanocrystals have become very interesting due to wide range of application possibilities. Curcumin was used as a model active ingredient in this work. Even though it has many proven positive effects, due to its physicochemical issues, its possibilities have not been fully exploited. The goal of this work was to select optimal conditions for a top-down method for curcumin nanosuspension production, and to perform their comprehensive characterization applying complementary methodologies: ...Ines Nikolić, Jelena Antić-Stanković, Dragana Božić, Danijela Ranđelović, Bojan Marković, Dominique Jasmin Lunter, Aleksandar Kremenović, Miroslav Savić, Snežana Savić. "Curcumin nanonization using an alternative small-scale production unit: selection of proper stabilizer applying basic physicochemical consideration and biological activity assessment of nanocrystals" in Review on advanced materials science, Walter de Gruyter GmbH (2020). https://doi.org/10.1515/rams-2020-0043
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Demise of the Wetterstein Carbonate Platform and onset of the Dachstein Carbonate Platform recorded in deep-water successions of the East Bosnian-Durmitor megaunit (Pliješevina, northern Montenegro, Dinarides)
Milica Mrdak, Eva Wagerer, Milan Sudar, Nevenka Djerić, Martin Đaković, Hans-Jürgen Gawlick. "Demise of the Wetterstein Carbonate Platform and onset of the Dachstein Carbonate Platform recorded in deep-water successions of the East Bosnian-Durmitor megaunit (Pliješevina, northern Montenegro, Dinarides)" in Geologica Carpathica, Central Library of the Slovak Academy of Sciences (2024). https://doi.org/10.31577/GeolCarp.2023.26
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Претрага корпуса заснована на употреби екстерних лексичких ресурса путем веб-сервиса
У раду се разматра хибридни приступ претрази корпуса, илустрован на примеру алатки OCWB и NoSketch Engine, примењених на специјални корпус из области рударства (РудКор) и Корпус савременог српског језика (СрпКор). Разматрани приступ комбинује постојеће могућности алатки OCWB и NoSketch Engine, које своју претрагу заснивају на лингвистичкој анотацији корпуса, са новим могућностима претраге у виду консултовања екстерних језичких ресурса (морфолошки електронски речници српског језика и лексичка база података Српски ворднет). Хибридни приступ је реализован надоградњом вебсучеља која поменуте алатке користе ...... Computational Linguistics in Bulgaria (CLIB 2018), May 27-29, 2018, Sofia, Bulgaria, ISSN 2367-5675 (on-line), 41–51, http://dcl.bas.bg/clib/wp-content/uploads/2018/06/CLIB_2018_Pro- ceedings_v1_final.pdf Рихли 2007: Pavel Rychlý, “Manatee/Bonito — A Modular Corpus Manager”, In: 1st Workshop on ...
... Compu- tational Linguistics in Bulgaria (CLIB 2018), May 27–29, 2018, Sofia, Bul- garia, ISSN 2367-5675 (on-line), 104–114, http://dcl.bas.bg/clib/wp-content/ uploads/2018/06/CLIB_2018_Proceedings_v1_final.pdf Томашевић и др. 2018: Aleksandra Tomašević, Ranka Stanković, Miloš Utvić, Ivan Obradović and ...Милош Утвић, Ранка Станковић, Александра Томашевић, Михаило Шкорић, Биљана Лазић. "Претрага корпуса заснована на употреби екстерних лексичких ресурса путем веб-сервиса" in Научни састанак слависта у Вукове дане - Vol. 48/3 Српски језик и његови ресурси, Међународни славистички центар, Филолошки факултет, Универзитет у Београду (2019). https://doi.org/10.18485/msc.2019.48.3.ch12
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The influence of Al<sup>3+</sup>ion on porcine pepsin activity<i>in vitro</i>
The in vitro effect of Al3þ ions in the concentration range 1.7·1026M–8.7·1023M on pepsin activity at pH 2, via kinetic parameters and its electrophoretic mobility was evaluated. Kinetic study demonstrated the existence of an activation effect of Al3þ at pH 2 on pepsin molecule. Kinetic analysis with respect to concentrations of haemoglobin showed that Al3þ ions increase the maximal velocity (Vmax) and kcat values rather than apparent affinity for substrate (KS) implying the non-competitive nature of activation which indicated ...... proteins of neuron plaques, shows that bounded aluminium ions causes significant conformational changes and induce increase in beta structure content (conversion alpha to beta up to 90%) [22]. AP? ion altered formation and stabilization of beta structure is probably direct consequence of complex ...
... aspartic proteases, it is possible that bounded aluminium ions causes significant conformational changes and induce increase in beta structure content [22,23,34]. As Al ions occur mostly in an ionic form in the acidic milieu (as [Al (H2O)6}" ) it probably affect electric charge of the molecules ...Vesna M. Pavelkić, Kristina R. Gopcević, Danijela Z. Krstić, Marija A. Ilić. "The influence of Al3+ion on porcine pepsin activityin vitro" in Journal of Enzyme Inhibition and Medicinal Chemistry, Informa UK Limited (2008). https://doi.org/10.1080/14756360701841095
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Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases
Ispitivani su uticaji primene mono- i dvokomponentnih organskih modifikatora na određivanje lipofilnosti 12 tetradentatnih Šifovih baza metodom reverzno-fazne tankoslojne hromatografije. Osnovni cilj je da se proceni tip interakcije između posmatranih jedinjenja i komponenti primenjenih hromatografskih sistema i uspostavi neki obrazac ponašanja kako bi se lakše izabrala kombinacija organskih modifikatora koji će simulirati interakciju u biološkim sistemima na osnovu činjenica da iste osnovne intermolekularne interakcije su odgovorne za ponašanje supstanci i u biološkom i u hromatografskom sistemu. Primenjeni organski modifikator ...Nikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, Rada Baošić. "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases" in Chemical Papers, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s11696-021-01884-5
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Stratigraphy and microfossils (radiolarians and planktonic foraminifers) of the Upper Cretaceous (upper Santonian–lower Campanian) Struganik limestone (Western Serbia)
Liubov G. Bragina, Nikita Yu. Bragin, Ludmila F. Kopayevich, Nevenka Đerić, Nataša Gerzina Spajić (2019)Liubov G. Bragina, Nikita Yu. Bragin, Ludmila F. Kopayevich, Nevenka Đerić, Nataša Gerzina Spajić. "Stratigraphy and microfossils (radiolarians and planktonic foraminifers) of the Upper Cretaceous (upper Santonian–lower Campanian) Struganik limestone (Western Serbia)" in Palaeoworld, Elsevier BV (2019). https://doi.org/10.1016/j.palwor.2019.05.001
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Компарација метода XRF i ICP-MS на узорцима угља и продуктима сагоревања
Бранко Костић, Ксенија Ераковић, Дејан Прелевић, Сабина Ковач, Драгана Животић. "Компарација метода XRF i ICP-MS на узорцима угља и продуктима сагоревања" in Записници Српског геолошког друштва (2023)
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Towards Semantic Interoperability: Parallel Corpora as Linked Data Incorporating Named Entity Linking
U radu se prikazuju rezultati istraživanja vezanih za pripremu paralelnih korpusa, fokusirajući se na transformaciju u RDF grafove koristeći NLP Interchange Format (NIF) za lingvističku anotaciju. Pružamo pregled paralelnog korpusa koji je korišćen u ovom studijskom slučaju, kao i proces označavanja delova govora, lematizacije i prepoznavanja imenovanih entiteta (NER). Zatim opisujemo povezivanje imenovanih entiteta (NEL), konverziju podataka u RDF, i uključivanje NIF anotacija. Proizvedene NIF datoteke su evaluirane kroz istraživanje triplestore-a korišćenjem SPARQL upita. Na kraju, razmatra se povezivanje Linked ...paralelni korpusi, povezivanje imenovanih entiteta, prepoznavanje imenovanih entiteta, NER, NEL, povezani podaci, NIF, VikipodaciRanka Stanković, Milica Ikonić Nešić, Olja Perisic, Mihailo Škorić, Olivera Kitanović. "Towards Semantic Interoperability: Parallel Corpora as Linked Data Incorporating Named Entity Linking" in Proceedings of the 9th Workshop on Linked Data in Linguistics @ LREC-COLING 2024, Turin, 20-25 May 2024, ELRA and ICCL (2024)
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A comparison between ARIMA, LSTM, ARIMA-LSTM and SSA for cross-border rail freight traffic forecasting: the case of Alpine-Western Balkan Rail Freight Corridor
Miloš Milenković, Miloš Gligorić, Nebojša Bojović, Zoran Gligorić. "A comparison between ARIMA, LSTM, ARIMA-LSTM and SSA for cross-border rail freight traffic forecasting: the case of Alpine-Western Balkan Rail Freight Corridor" in Transportation Planning and Technology, Informa UK Limited (2023). https://doi.org/10.1080/03081060.2023.2245389
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A Description of Morphological Features of Serbian: a Revision using Feature System Declaration
In this paper we discuss some well-known morphological descriptions used in various projects and applications (most notably MULTEXT-East and Unitex) and illustrate the encountered problems on Serbian. We have spotted four groups of problems: the lack of a value for an existing category, the lack of a category, the interdependence of values and categories lacking some description, and the lack of a support for some types of categories. At the same time, various descriptions often describe exactly the same ...... management - Feature Structures – Part 2: Feature System Declaration, ISO/TC 37/SC 4. ISO. (2009) ISO 12620 Terminology and other language and content resources – Data Categories – Specification of data categories and management of a data category registry for language resources Kešelj, V., Kešelj ...Cvetana Krstev, Ranka Stanković, Vitas Duško. "A Description of Morphological Features of Serbian: a Revision using Feature System Declaration" in Proceedings of the 5th International Conference on Language Resources and Evaluation, LREC 2010, Valetta, Malta : European Language Resources Association (2010)
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Formative evaluation of e-learning projects with the logical framework approach
... offered for their translation. The conceptual model of the ICT solution for BAEKTEL OER framework envisages a network of nodes offering OER content and a central repository, the BAEKTEL Metadata Portal (BMP), where metadata, providing all important information on the network resources will ...Roberto Linzalone, Giovani Schiuma, Ivan Obradović, Ranka Stanković. "Formative evaluation of e-learning projects with the logical framework approach" in The Sixth International Conference on e-Learning (eLearning-2015), September 2015, Belgrade, Serbia, Belgrade Metropolitan Univesity (2015)
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Development of A Business Intelligence Tool For Accident Analysis in Mines
... n of a taxonomy-based navigation tool called “Site Browser” (http://wwwn.cdc.gov/niosh-mining) that allows researchers and other users to browse content tagged with subject terms from their taxonomy. Besides improving their performance using ICT, companies within Serbian mining industry are also ...Ljiljana Kolonja, Ranka Stanković, Ivan Obradović, Olivera Kitanović, Uroš Pantelić. "Development of A Business Intelligence Tool For Accident Analysis in Mines" in Proceedings of the 5th International Symposium Mining And Environmental Protection, June 10-13, 2015, Vrdnik, Serbia, Belgrade : Faculty of Mining and Geology (2015)
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Terminological and lexical resources used to provide open multilingual educational resources
Open educational resources (OER) within BAEKTEL (Blending Academic and Entrepreneurial Knowledge in Technology enhanced learning) network will be available in different languages, mostly in the languages of Western Balkans, Russian and English. University of Belgrade (UB) hosts a central repository based on: BAEKTEL Metadata Portal (BMP), terminological web application for management, browse and search of terminological resources, web services for linguistic support (query expansion, information retrieval, OER indexing, etc.), annotation of selected resources and OER repository on local edX ...... Learning, 2013, pp. 65–70. http://termi.rgf.bg.ac.rs/ [6] R. Stanković, D. Carlucci, O. Kitanović, N. Vulović and B. Zlatić, “LRMI markup of OER content within the BAEKTEL project,” in Proc. 6th International Conference on e-Learning (eLearning-2015), 2015, pp. 98–103. [7] C. Krstev, Processing of ...Biljana Lazić, Danica Seničić, Aleksandra Tomašević, Bojan Zlatić. "Terminological and lexical resources used to provide open multilingual educational resources" in The Seventh International Conference on eLearning (eLearning-2016), 29-30 September 2016, Belgrade, Serbia, Belgrade : Belgrade Metropolitan University (2016)
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Conversion of land areas after coal mine closure and reclamation
Otkopavanje uglja površinski i podzemno praćeno je degradacijom zemljišta, promenom formiranja predela i izmenom flore i faune. Od velikog značaja je razvoj novih naučno utemeljenih pristupa obnovljanje antropogeno poremećenih predela zasnovanih na formiranju rekultivacionih i rudarskih tehnologija. Apsolutno je neophodno obezbediti sveobuhvatno kvalitetno očuvanje zemljišnih i vodnih resursa i odrediti rekultivisano zemljište za novu namenu. U ovom članku je dat pregled najpopularnijih metoda rekultivacije zemljišta i mogućnosti rekultivacije zemljišta nakon završetka rekultivacije i zatvaranja rudnika uglja.... geometric distance from . NINA NR performance for each alternative | an alternative is added to or the positive ideal : : . :. : in a simple mathematical form. | removed from the decision solution problem. Logical Use simple diagrams to Framework P d Clarify the cause and Greatly affected by ...
... mining region. REFERENCES 1. 2. 10. 11. Ignatyeva, M., Yurak, V., Pustokhina N. Recultivation of Post-Mining Disturbed Land: Review of Content and Comparative Law and Feasibility Study. Resources 2020, 9, 73. https://doi.org/10.3390/ Group of authors, Land «#rehabilitation guidelines . for ...Radmila Gaćina, Bojan Dimitrijević, Sanja Bajić. "Conversion of land areas after coal mine closure and reclamation" in 9th International conference mining and environmental protection MEP 23 Proceedings, Sokobanja, 24-27.05.2023., Belgrade : University of Belgrade - Faculty of mining and geology (2023)
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Composition of organic matter and thermal maturity of Mesozoic and Cenozoic sedimentary rocks in East Herzegovina (External Dinarides, Bosnia and Herzegovina)
This paper presents the first data on the organic matter and thermal maturity of Mesozoic and Cenozoic sedimentary rocks in the East Herzegovina region of the External Dinarides. Representative, organic-rich samples from outcropping sedimentary rocks of different ages in the area (Triassic to Neogene) were selected and analysed. The organic matter was studied by Rock-Eval pyrolysis and under the microscope in reflected non-polarized light and incident blue light. The results obtained show the presence of different types of organic ...... the south), and near Trebinje (Pridvorci and Todorići, in the south), and are all from thin-layered brown limestone, with a signi�cant, visible content of organ- ic matter (resembling microbial mats). As a good example, the Pridvorci site consists of thin-bedded, laminated lime- stones, rich in organic ...
... the south), and near Trebinje (Pridvorci and Todoric¢i, in the south), and are all from thin-layered brown limestone, with a significant, visible content of organ- ic matter (resembling microbial mats). As a good example, the Pridvorci site consists of thin-bedded, laminated lime- stones, rich in organic ...
... of Rock-Eval pyrolysis, in- cluding maturity parameter T max,x , are shown in Tables 1, 2 and Figure 4. �e total organic carbon (TOC, wt.%) content is over 0.45% in all samples analysed. �e Triassic samples (No. 1–4) Locality Age* Sample TOC (%) S1 (mg HC/g rock) S2 (mg HC/g rock) HI (mg ...Nikoleta Aleksić, Aleksandar Kostić, Miloš Radonjić. "Composition of organic matter and thermal maturity of Mesozoic and Cenozoic sedimentary rocks in East Herzegovina (External Dinarides, Bosnia and Herzegovina)" in Annales Societatis Geologorum Poloniae (2021). https://doi.org/10.14241/asgp.2021.16
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Using English Baits to Catch Serbian Multi-Word Terminology
In this paper we present the first results in bilingual terminology extraction. The hypothesis of our approach is that if for a source language domain terminology exists as well as a domain aligned corpus for a source and a target language, then it is possible to extract the terminology for a target language. Our approach relies on several resources and tools: aligned domain texts, domain terminology for a source language, a terminology extractor for a target language, and a ...aligned texts, word alignment, terminology extraction, electronic dictionaries, morphological inflection... lemmatization was ap- plied to the English parts of the aligned chunks. English parts of the aligned chunks that do not have at least one lem- matized content word present in the lemmatized BoW Dic- tionary representation were eliminated. Along with original and lemmatized form of chunks and their counts ...
... matches some term in the Dictionary – S(align.chunk) ∼ S(term.dict) – and the Serbian part is a multi-word chunk, that is, it contains at least 2 content words) was 11,678. 2. In the next step the additional filtering was done – (T (align.chunk) ∼ T (term.list)) ∧ (T (term.list) ↔ S(term.dict)) ∧ (S(term ...Cvetana Krstev, Branislava Šandrih, Ranka Stanković. "Using English Baits to Catch Serbian Multi-Word Terminology" in Proceedings of the 11th International Conference on Language Resources and Evaluation, LREC 2018, Miyazaki, Japan, May 7-12, 2018, European Language Resources Association (ELRA) (2018)
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Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica
Nature and Landscape Conservation, Soil Science, Agronomy and Crop Science, Water Science and TechnologyNatalija Momirović, Ratko Kadović, Veljko Perović, Miloš Marjanović, Aleksandar Baumgertel. "Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica" in International Soil and Water Conservation Research, Elsevier BV (2019). https://doi.org/10.1016/j.iswcr.2018.12.004
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Development of a petrographic classification system for organic particles affected by self-heating in coal waste. (An ICCP Classification System, Self-heating Working Group – Commission III)
M. Misz-Kennan, J. Kus, D. Flores, C. Avila, Z. Büçkün, N. Choudhury, K. Christanis, J.P. Joubert, S. Kalaitzidis, A.I. Karayigit, M. Malecha, M. Marques, P. Martizzi, J.M.K. O'Keefe, W. Pickel, G. Predeanu, S. Pusz, J. Ribeiro, S. Rodrigues, A.K. Singh, I. Suárez-Ruiz, I. Sýkorová, N.J. Wagner, D. Životić (2020)Self-heating of coal waste is a major problem in the leading coal-producing and consuming countries, independent of the recent or past coal exploitation history. The phenomenon of self-heating is dependent on many factors such as the properties of organic matter (maceral composition and rank), moisture and pyrite content, climate effects, and storage conditions (shape of the dump or compaction of the coal waste). Once deposited, coal waste undergoes oxidation, which can lead to self- heating with the overall temperatures ...M. Misz-Kennan, J. Kus, D. Flores, C. Avila, Z. Büçkün, N. Choudhury, K. Christanis, J.P. Joubert, S. Kalaitzidis, A.I. Karayigit, M. Malecha, M. Marques, P. Martizzi, J.M.K. O'Keefe, W. Pickel, G. Predeanu, S. Pusz, J. Ribeiro, S. Rodrigues, A.K. Singh, I. Suárez-Ruiz, I. Sýkorová, N.J. Wagner, D. Životić. "Development of a petrographic classification system for organic particles affected by self-heating in coal waste. (An ICCP Classification System, Self-heating Working Group – Commission III)" in International Journal of Coal Geology, Elsevier BV (2020). https://doi.org/10.1016/j.coal.2020.103411
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Prvi nalazi repatih vodozemaca (Urodela) u pleistocenskoj pećinskoj fauni Srbije; još jedna kockica u slagalici
Fosilna fauna pleistocenskih pećina odslikava sastav faune njihove okoline. Najčešće se u njima naleze ostaci krupnih sisara ledenog doba koji su je koristili kao stanište. Uz njih česti su i ostaci drugih sitnih kičmenjaka kao što su sitni sisari, ribe, vodozemci, gmizavci i ptice. Ostaci sitnih kičmenjaka u većini slučajeva u pećinu dospevaju kao plen grabljivica (ptice i sisari) ali je manji broj njih pećinu koristio i kao sklonište ili stanište. U proučavanje fluktuacija pleistocenske klime sve češće se ...... Fojnica, BiH Tiraž: 150 primjeraka Napomena: 4ufori su odgovorni za sadržaj i kvalitet svojih radova Note: 7he authors are responsible for the content and quality of their papers ZBORNIK RADOVA III KONGRES GEOLOGA BOSNE I HERCEGOVINE ISSN 1840-4073 UDRUŽENJE / UBRUGR GEDLOGR BOSNE I HERCEGOVINE ...Dragana Đurić, Katarina Bogićević, Draženko Nenadić, Mihajlo Jovanović, Aleksandra Savković. "Prvi nalazi repatih vodozemaca (Urodela) u pleistocenskoj pećinskoj fauni Srbije; još jedna kockica u slagalici" in Zbornik sažetaka III Kongresa geologa Bosne i Hercegovine sa međunarodnim učešćem. Neum, 21.-23. septembar/rujan 2023, Ilidža : Udruženje geologa Bosne i Hercegovine (2023)