Претрага
731 items
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The Rift Sequence Stratigraphy of the Itebej Field (Pannonian Basin, Serbia)
... Central Paratethys, Itebej field, rift sequence stratigraphy, reef sediments, petroleum system References Tari, G., P. Dovenyi, I. Dunkl, F. Horvath, L. Lenkey, M. Ștefănescu, P. Szafian, and T. Toth, 1999. Lithospheric structure of the Pannonian basin derived from seismic, gravity and geothermal ...
... extension within the Alpine Orogen, edited by B. Durand, L. Jolivet, F. Horvath and M. Serrane, pp. 215-250, Geol. Soc. London Spec. Publ. 156. ABSTRACTS P - 139 ...Saša Ivanišević, Jelena Radišić, Ivana Isić, Dejan Radivojević. "The Rift Sequence Stratigraphy of the Itebej Field (Pannonian Basin, Serbia)" in AAPG Vienna, Paratethys petroleum systems between Central Europe and the Caspian Region, Vienna, 26-27 mart, 2019, AAPG (2019)
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Rock slope stability analysis under Hoek–Brown failure criterion with different flow rules
The stability analysis of homogeneous rock slope following the Hoek–Brown failure criterion under the hypothesis of different flow rules is performed based on limit equilibrium and finite element methods. The applied failure criterion is the generalized Hoek–Brown that can be introduced as a shear/normal function in analysis applying different flow rules. The results are compared with those obtained by the application of equivalent shear strength parameters of the Mohr–Coulomb criterion, considering that this is still the most widely used ...Kružna klizna površ, Huk-Braunov kriterijum loma, Kriterijum popuštanja, Smičuća/normalna funkcija, Nivo napona, Verovatnoća i parametarska analizaSvetlana Melentijević, Zoran Berisavljević, Dušan Berisavljević, Claudio Olalla Marañón . "Rock slope stability analysis under Hoek–Brown failure criterion with different flow rules" in Bulletin of Engineering Geology and the Environment , Springer (2024). https://doi.org/10.1007/s10064-024-03667-0
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Callovian (Middle Jurassic) Sphriganaria (Brachiopoda) from the Jordan Valley (Middle East)
Howard R. Feldman, Barbara V. Radulović, Fayez Ahmad. "Callovian (Middle Jurassic) Sphriganaria (Brachiopoda) from the Jordan Valley (Middle East)" in Historical Biology (2023). https://doi.org/10.1080/08912963.2022.2122823
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Upravljanje proizvodnjom nafte – novi alat na bazi fazi logike
... April 20, 2019, p. 86-93. [2] Kibona D, Kidulile G, Rwabukambara F., “Environment, climate warming and water management”. Transit Stud Rev, vol. 16, p. 484–500. 2009. [3] Cassardo C, Jones JAA.,” Managing water in a changing world. Water”, vol. 3, p. 618–628. 2011. [4] Gleick, P. H., “Water resources” ...
... Ekonomika poljoprivrede, Beograd, br.1-2/2004. [7] Petrović, P., 2006, Preduzetnički menadžment, PMF, Novi Sad. [8] Petrović, P., 2008, Turizam i poslovna diplomatija, PMF Novi Sad, Departman za geografiju, turizam i hotelijerstvo. [9] Petrović, P., 2019, Srbija i novi društeno ekonomski poredak, Institut ...
... The Irish Journal of Psychology, vol. 27, no. 3, p. 130-141. [10] Vaijayanthi, P., Shreenivasan, K. A. and Prabhakaran, S. (2011). Employee Engagement predictors: A study at GE Power & Water. International Journal of Global Business, vol. 4, no. 2, p. 60. [11] Wilkinson, A. (1999). Employment relations ...Мирослав Црногорац, Душан Даниловић, Лола Томић. "Upravljanje proizvodnjom nafte – novi alat na bazi fazi logike" in IX Naučno stručni skup Preduzetništvo, inženjerstvo i menadžment Zrenjanin, 24.10.2020. god., Visoka tehnička škola strukovnih studija u Zrenjaninu (2020)
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Development of Open Educational Resources (OER) for Natural Language Processing
In this paper we present the development of an online course at the edX BAEKTEL platform named “Lexical Recognition in the Natural Language Processing (NLP)”. It is based on the course of the same name for PhD studies at the University of Belgrade, Faculty of Philology. There are not many courses in Computational Linguistics (CL) on OER platforms, and there is none in Serbian either for CL or NLP. We have developed this course in order to improve this ...... Innovation and Entrepreneurship: Connecting the Knowledge Dots, J. Spender, G. Schiuma, and V. Albino, Editors. 2015: Bary, Italy. p. 1801-1812. [2] Jackson, P. and I. Moulinier, Natural Language Processing for Online Applications: Text Retrieval, Extraction and Categorization. 2002: John Benjamins ...
... 40(2): p. 152-162. [9] Krstev, C., Information Science Curriculum at the Undergraduate Studies of Library and Information Science, in Skup bibliotekara balkanskih zemalja: Saradnja obrazovanje kvalitet, A. Vraneš and L. Marković, Editors. 2002, Narodna biblioteka Srbije: Belgrade. p. 117-122 ...
... Linguistics, M. Gross and D. Perrin, Editors. 1989, Springer Berlin Heidelberg. p. 34-50. [13] Vitas, D. and C. Krstev, Processing of Corpora of Serbian Using Electronic Dictionaries. Prace Filologiczne, 2012. LXIII: p. 279-292. [14] Utvić, M., Izgradnja referentnog korpusa savremenog srpskog ...Cvetana Krstev, Biljana Lazić, Ranka Stanković, Giovanni Schiuma, Miladin Kotorčević. "Development of Open Educational Resources (OER) for Natural Language Processing" in The Sixth International Conference on e-Learning (eLearning-2015), September 2015, Belgrade, Serbia, Belgrade : Belgrade Metropolitan Univesity (2015)
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Investigation of quantitative indicators of anisotropy based on longitudinal elastic waves propagation velocities with uncertainty
... re e o f a n is o tr o p y , % Serial number of sample Degree of anisotropy for each special isotropic sample including all of the directions DIi,max DIi,min 0.00 50.00 100.00 150.00 200.00 250.00 0 5 10 15 20 25 30 D e g re e o f a n is o tr o p y , % Serial number of sample ...
... o tr o p y c o e ff ic ie n t, % Serial number of sample Anisotropy coefficient for each special isotropic and anisotropic sample including all of the directions KIi,mean KAi,mean 0.0 20.0 40.0 60.0 80.0 100.0 120.0 140.0 1 2 3 D e g re e o f a n is o tr o p y , % Number ...
... 0 1 2 3 D e g re e o f a n is o tr o p y , % Number of directions Degree of anisotropy for each special direction icluding all of the anisotropic samples DAj,max DAj,min 0.0 20.0 40.0 60.0 80.0 100.0 120.0 1 2 3 A n is o tr o p y c o e ff ic ie n t, % Number of directions ...Miloš Gligorić, Jelena Majstorović, Suzana Lutovac. "Investigation of quantitative indicators of anisotropy based on longitudinal elastic waves propagation velocities with uncertainty" in Underground Mining Engineering, Belgrade : University of Belgrade - Faculty of Mining and Geology (2018). https://doi.org/10.5937/PodRad1832001G
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Late Triassic radiolarians from the Grivska formation, internal Dinarides, SW Serbia
Paleontology, Stratigraphy, Economic Geology, Geochemistry and Petrology, Geology, Geophysics, Geotechnical Engineering and Engineering Geology... 2003) and Zone Capnodoce Eptingiidae ? gen. et sp. indet. R crystallina of Eastern Russia .. Palaeosaturnalis sp. |-- J ” | m M | P | P | m P | = P | G O | P | G O | Q m | > (BRAciN, 2000). Praehexasaturnalis tenuispinosus (DONOFRIO & MOSTLER) Paronaella sp. Triassocrucella sp. cf. T. ...
... NEWPoORT, 1972 and DUMITRICA, 1970, residues were washed by water, then cleaned by hot water (10—15 g) with 0.5 g tetra- sodium pyrophosphate (Na„,P.,O,) to remove clay par- ticles. Radiolarians were picked from dried residues under light binocular microscope LOMO-MBS-10, Fig. 2. Limestones oftthe ...
... series: Emile Argand Conference - 13th Workshop on Alpine Ge- ological Studies, September 7th-18th 2017, Zlatibor Mts. (Serbia), Abstract volume, p. 22, University of Belgrade, Faculty of Mining and Geology, Belgrade. BRAGIN, N., BRAGINA, L., GERZINA SPAJIĆ, N., DJERIĆ, N. & SCHMID, S. 2018 ...Nikita Bragin, Liubov Bragina, Nevenka Đerić, Nataša Gerzina-Spajić. "Late Triassic radiolarians from the Grivska formation, internal Dinarides, SW Serbia" in Geološki anali Balkanskoga poluostrva (2019). https://doi.org/10.2298/GABP1901017B
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Primena AHP и WoEmetode u proceni podložnosti terena na kliženje za područje opštine Krupanj
Biljana Abolmasov, Jelka Krušić, Katarina Andrejev, Miloš Marjanović, Ranka Stanković, Uroš Đurić (2017)... WoE Osetljivost TPR=TP/P=TP/(TP + FN) 0,718727 0,706291 Specifičnost SPC=TN/N=TN/(FP + TN) 0,556080 0,606018 Stopa lažno pozitivnih (FPR) FPR=FP/N=FP/(FP + TN) 0,443919 0,393981 Stopa lažno negativnih (FNR) FNR=FN/P =FN(TP + FN) 0,281272 0,293708 Tačnost ACC=(TP + TN)/(P + N) 0,557258 0,606744 ...
... rasprostranjenje na istraž- nom području. Razlikuju se dva superpoziciona paketa: srednji perm (P 2 ) predstavljen terigenim sedimentima – kvarcnim peščarima i peskovito – glinovitim škriljcima i mlađim (P 3 ) predstavljenim slojevitim krečnjacima, glin- cima i peščarima. Sedimenti mezozoika su p ...
... negativnih qij “dokaza“, a na osnovu njihovih težinskih faktora. Težina dokaza (Weight of Evidence) – wij se računa na sledeći način (jednačina 2): W p q ij ij ij = ln (2) gde je: pij – broj pozitivnih “dokaza“za klasu j, i-tog parametra, podeljen ukupnim brojem pozitivnih ...Biljana Abolmasov, Jelka Krušić, Katarina Andrejev, Miloš Marjanović, Ranka Stanković, Uroš Đurić . "Primena AHP и WoEmetode u proceni podložnosti terena na kliženje za područje opštine Krupanj" in Izgradnja, Beograd : Udruženje inženjera građevinarstva, geotehnike, arhitekture i urbanista Izgradnja (2017): 239-246
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BEYOND 2020 - Geology explorations and open pit activities affectation in reclamation designing in Kolubara Coal Mines (KCM) Serbia, new considerations
Geology explorations in KCM runs from 1936. year up to these days and still ongoing. Results in >7,200 drill holes with ≈600,000 m of core drilling and gave lignite ore resources of > 4,1Bt, which 1,15Bt are excavated since 1986. of XIX up to early years of XXI century. For further mining operations in open pits stay 1,5Bt of lignite. Under waste heaps are ≈80 km2, additional 85 km2 should be filled. All of that masses/areas were, are ...Bojan Dimitrijević, Bogoljub Vučković, Radmila Gaćina. "BEYOND 2020 - Geology explorations and open pit activities affectation in reclamation designing in Kolubara Coal Mines (KCM) Serbia, new considerations" in 17th International Conference of the open and underwater mining of minerals, Sts. Constantine and Helena Resort, Varna, 18-22 September, Bulgaria, Sofia, Bulgaria : Scientific and Technical Union of Mining, Geology and Metallurgy, (2023)
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Neogena i kvartarna herpetofauna (Anura i Squamata) Srbije : doktorska disertacija
Dragana D. Đurić (2019)U radu je prvi put opisan deo herpetofaune (Anura i Squamata) iz neogenih i kvartarnih lokaliteta Srbije. Obrađeni su lokaliteti Sibnica, Prebreza, Lazarevc, Vračević i Riđake, neogene starosti. Lokaliteti kvartarne starosti su pećine Mala i Velika Balanica, Pešturina, Hadži Prodanova, Baranica, Vrelska pećina i sedimentne ispune fisura u kamenolomima Venčac i Beočin. U radu je prikazana je taksonomska analiza herpetoloških ostataka. Pored taksonomske analize fosilnog materijala dat je kratak geografsko-geološki opis proučavanih lokaliteta, osnovne osteološke karakteristike anura i skvamata ...... zastupljen je sa dve vrste – P. laurilardi i P. pannonicus, koji se za razliku od savremenog P. apodus sreću u delimično i izrazito vlažnim staništima obraslim šumom (Klembara et al. 2010). Herpeto–asocijacija iz Lazarevca, koju čine Agama s.l., Pseudopus sp. P. cf. P. laurillardi, Ranidae, nešto ...
... (Biton et al. 2016). Izumrle vrste Pseudopus-a, P. laurillardi i P. pannonicus, zajedno sa savremenom vrstom Pseudopus apodus, ilustruju povlačenje ovog roda od zapada Evrope ka jugoistoku Evroazije (Klembara & Rummel 2018). Pseudopus laurillardi i P. Pannonicus, za razliku od recentnog srodnika, ...
... aridizaciji prostora Srbije od miocena do danas. Od pet izumrlih taksona, četiri (Latonia gigantea, Palaeobatrachus sp., Pseudopus cf. P. laurillardi i P. cf. P. pannonicus) su iz miocenskih lokaliteta sa toplom i vlažnom klimom. Izumrla Zamenis paralongissimus prvi put je u Srbiji identifikovana u ...Dragana D. Đurić. Neogena i kvartarna herpetofauna (Anura i Squamata) Srbije : doktorska disertacija, Beograd : Rudarsko-geološki fakultet, 2019
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Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica
Nature and Landscape Conservation, Soil Science, Agronomy and Crop Science, Water Science and TechnologyNatalija Momirović, Ratko Kadović, Veljko Perović, Miloš Marjanović, Aleksandar Baumgertel. "Spatial assessment of the areas sensitive to degradation in the rural area of the municipality Čukarica" in International Soil and Water Conservation Research, Elsevier BV (2019). https://doi.org/10.1016/j.iswcr.2018.12.004
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Equilibrium and kinetic studies of the reactions between [Ru(terpy)(bipy)Cl]Cl complex and biologically important N-donor ligands
Studije u oblasti antikancerogenih karakteristika jedinjenja rutenijuma(III/II) izazivaju veliku pažnju već nekoliko godina otkako su neka od njih kao što su KP1019 (indazolijum-tetrahloridobis(H-indazol)rutenat(III)) i NAMI-A (imidazolijum) -trans-tetrahlorido(dimetilsulfoksid)indazolerutenat(III)) dostigao nivo kliničkog ispitivanja. Kompleksi rutenijuma u reakciji sa molekulom DNK formiraju prvenstveno gvanin- i adenin-adukt, kao komplekse platine. Takođe, nekoliko studija ukazuje na veoma jake interakcije sa proteinima. Međutim, kompleksi Ru(III/II) pokazuju generalno manje toksične efekte od lekova platine(II).1 Proučavali smo kinetiku reakcija supstitucije kompleksa [Ru(terpi)(bipi)Cl]Cl sa biološki važnim ligandima: dimetilsulfoksidom, gvanozin-5’-monofosfatom, ...Aleksandar Mijatović, Biljana Petrović, Ratomir Jelić, Živadin Bugarčić. "Equilibrium and kinetic studies of the reactions between [Ru(terpy)(bipy)Cl]Cl complex and biologically important N-donor ligands" in EuroAnalysis 16 - Challenges in Modern Analytical Chemistry, Belgrade : Division of Analytical Chemistry of the Serbian Chemical Society (2011)
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Sprega neuronskih mreža i numeričkih modela zadefinisanje sigurnih rastojanja kod razletanja komada pri miniranju
Saša S. Stojadinović (2013-09-16)Doktorska disertacija sa navedenim naslovom prezentuje rezultate istraživanjaproblema razletanja komada pri miniranjima. Cilj istraživanja bio je kreiranje opšteg iuniverzalno primenljivog modela za prognozu maksimalnih dometa razletelih komada idefinisanje sigurnih rastojanja. Kombinacijomterenskih istraživanja, numerikogmodeliranja balistikih trajektorija razletelih komada i adaptivne prirode neuronskihmreža definisan je koncept neuro-numerike sprege. Sprega je objedinila univerzalnuprimenljivost numerikog modela i sposobnost prilagoavanja neuronskih mrežalokalnim uslovima u opšti model za prognozu maksimalnih dometa razletelih komada.Za potrebe sprege, a kao integralni deo disertacije, razvijen je metod za odreivanjekoeficijenta ...Razletanje, miniranje, domet, sigurna rastojanja, numeriki modeli,neuronske mreže, sprega, verifikacija...500 Internal Server Error Internal Server Error
<p>The server encountered an internal error and was unable to complete your request. Either the server is overloaded or there is an error in the application.p> ...Saša S. Stojadinović. "Sprega neuronskih mreža i numeričkih modela zadefinisanje sigurnih rastojanja kod razletanja komada pri miniranju" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2013-09-16)
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Serbian Society of Geomorphologists
Dragana Đurić, Jelena Ćalić (2019)Dragana Đurić, Jelena Ćalić. "Serbian Society of Geomorphologists" in GeomorForum 2019: Landforms related to plains of Serbia and its neighboring area, Conference Programme and Abstracts, Beograd, 10-12. maj 2019, Serbian Society of Geomorphologists (2019)
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FTIR spectroscopic study оf S-мetolachlor сorption оn inorganic and organically modified montmorillonite from Bogovina
... s i s BOA A H || s|--38 8 P A g s - | „ihi š š - | || +NM a 3i af Š | 5 š [ IB || P || \8 ti o E \, 8 \ i 33 MA š šš ž B NaM EE “0 300 200 100 1500 1000 Wavenumber {cm ) Wavenumber {cm ') š 18p f) PTMA |j | |ž š \|E a E 13 i - PMV A | i n g"VA/B i g .| š P E Hi )s i . H | Š PONE ...
... r, V., Makreski, P..2012. NIR and MIR spectroscopic characteristics of hydrophilic and hydrophobic bentonite treated with sulphuric acid. Vib. Spectrosc., 58, 95-—103. DOI: 10.1016/J.vibspec.2011.11.002 Tomić, P.Z., Ašanin, P.D., Đurović-Pejčev, R., Đorđević, A., Makreski, P., 2015. Adsorption ...
... metolachlor in soil: effect of new organoclay formulations. Pestic. Sci., 55, 857— 864. DOI: 10.1002/(SICI)1096-9063(199908)55:8<857::AID-PS24>3.0.CO:2-P El-Nahhal, Y., Nir, S., Serban, C., Rabinovitz, O., Rubin, B., 2001. Organoclay formulation of acetochlor for reduced movementin soil. J. Agric. Food ...Lazar Kaluđerović, Zorica Tomić, Jelena Bogosavljević, Ljubomir Životić, Maja Milošević. "FTIR spectroscopic study оf S-мetolachlor сorption оn inorganic and organically modified montmorillonite from Bogovina" in Book of Proceedings / 3rd International and 15th National Congress Soils for Future Under Global Challenges, 21-24 September 2021 Sokobanja, Serbia , Belgrade : Serbian Society of Soil Science (2021)
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Evidence of Variscan and Alpine tectonics in the structural and thermochronological record of the central Serbo-Macedonian Massif (south-eastern Serbia)
... Jo oJenbs uvojA| a uonv|no|eo e p u posn sdojs Surinp poseo|o: 1y e JO 9861U9010d „ posvojor ı V e % OS< Ueds pue *0 G UUUJ SSO| Aq Joy}ip 1eU} Soyep ojqeusmSunsıp p[otX jeup sdoys Suneou snon8nuoo č< Jo o p uboul poyuSioA A *(neoyp{d o ...
... 18 0.0030. P 016 Fa = 330 i 0.0025 Š 0 Šou H q ŽNN 0.0 Š ol esnava.oam —— NN | lStaMa.gz a 052000 734Ma-2.01% WM:298.9+7.6Ma kitaod 270 MSWD?L 0.06 | -— MSWD3658 260 0.0005 ——p šš PaL_ _ _____ ii TEA — 240 0.02. 0.0000. — 0 o D O O O G 0 80 90 00 9 % O 4 O 6 70 85 80 100 0000 p&6o5 0607 0SGIO ...
... to authorized users. P< Milorad D. Antić m.antic('unibas.ch Institute for Geology and Palaeontology, University of Basel, 4056 Basel, Switzerland Faculty of Mining and Geology, University of Belgrade, Belgrade 11000, Serbia Section des Sciences de la Terre et de P Environnement, Universitć ...Milorad D. Antić, Alexandre Kounov, Branislav Trivić, Richard Spikings, Andreas Wetzel. "Evidence of Variscan and Alpine tectonics in the structural and thermochronological record of the central Serbo-Macedonian Massif (south-eastern Serbia)" in International Journal of Earth Sciences, Springer Science and Business Media LLC (2016). https://doi.org/10.1007/s00531-016-1380-6
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Atmospheric exposure vs burying: influences on damage intensity of built-in kersantite in the monument of the Small Staircase (Belgrade, Serbia)
Proučavan je efekat „zatrpanog kamena“ na intenzitet procesa degradacije prisutnih na kersantitu koji je ugrađen u spomenik Malo stepenište. Istraživanja su vršena na uzorcima stene iz kamenoloma i na oštećenim kamenim blokovima ugrađenim u spomenik. Dok su neki delovi stepeništa bili pod zemljom 90 godina, većina kamenih elemenata je bila izložena različitim uslovima sredine i antropogenim uticajima. Urađeno je detaljno mapiranje trenutnog stanja spomenika kako bi se istražio uticaj “zatrpavanja” i kompleksne geometrije spomenika na tip propadanja i variranje ...Nevenka Novaković, Predrag Dabić, Vesna Matović. "Atmospheric exposure vs burying: influences on damage intensity of built-in kersantite in the monument of the Small Staircase (Belgrade, Serbia)" in Environmental Earth Sciences, Springer Science and Business Media LLC (2023). https://doi.org/10.1007/s12665-023-10794-6
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Insights into dike nucleation and eruption dynamics from high-resolution seismic imaging of magmatic system at the East Pacific Rise
Milena Marjanović, Suzanne M. Carbotte, Alexandre Stopin, Satish C. Singh, René-Édouard Plessix, Miloš Marjanović, Mladen R. Nedimović, Juan Pablo Canales, Hélène D. Carton, John C. Mutter, Javier Escartín (2023)Milena Marjanović, Suzanne M. Carbotte, Alexandre Stopin, Satish C. Singh, René-Édouard Plessix, Miloš Marjanović, Mladen R. Nedimović, Juan Pablo Canales, Hélène D. Carton, John C. Mutter, Javier Escartín. "Insights into dike nucleation and eruption dynamics from high-resolution seismic imaging of magmatic system at the East Pacific Rise" in Science Advances, American Association for the Advancement of Science (AAAS) (2023). https://doi.org/10.1126/sciadv.adi2698
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Fluid inclusion systematics in the Okoška gora polymetallic deposit
... Planetary Change, 20 103475. Mioč,P. 1972: Basic Geological Map of Yugoslavia 1:100.000. Sheet Slovenj Gradec. Interpreli to the Sheet Slovenj Gradec. Federal Geological Survey Belgrade, 74 pp. Schmid, S. M., Fiigenschuh, B., Kounov, A., Matenco,L., Nievergelt, P.. Oberhinsli, R., Picuge Schefer, ...
... Early Cambrian crustal growth and orogenic zonih, Авсап Стаоп—Сопзтани from U-Pb zircon ages ani Germany). - Precambrian Research, 224, 236–278. Mioč, P. 1972: Basic Geological Map of Yugoslavia 1:100.000.5 to the Sheet Slovenj Gradec. Federal Geological Survey B Sigesmund,S., Oriolo, S., Heinrichs, ...
... but at the outcrop scale veins of transparentquartz intersectvi amethyst (Janez Žavašnik, verbal comm.), suggesting the later's earlier paragenetic p Fluid inclusion systematics A total of 100 fluid inclusions in sphalerite and quartz from five samples of ore were investigated in this study. Both ...Aleš Šoster, Miloš Velojić, Barbara Potočnik Krajnc, Matej Dolenec. "Fluid inclusion systematics in the Okoška gora polymetallic deposit" in 25th meeting of Slovenian geologists, Ljubljana, 2021, Univerza v Ljubljani, Oddelek za geologijo (2021)
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... nanosus- pensions decreased to the values similar to the ones in the corresponding suspensions (p = 0.563 and 0.965 for F5 vs. S5, and F6 vs. S6, respectively, Student t-test) except in the case of F9 (p < 0.01, Student t-test). In this formulation, the solubility of DK-I-60-3 in 0.1 M HCl was surprisingly ...
... fasted and fed state (p = 0.998 and 0.100 for Cmax and AUC, respectively, Student t-test). In investigated solid tissues, although average values of AUC seem to be different, even two times higher in the group of fed animals, statistically the differences were not significant (p = 0.933, 0.484, and 0 ...
... B.; Van den Mooter, G.; Augustijns, P. Top-down production of drug nanocrystals: Nanosuspension stabiliza- tion, miniaturization and transformation into solid products. Int. J. Pharm. 2008, 364, 64–75. [CrossRef] 16. Siewert, C.; Moog, R.; Alex, R.; Kretzer, P.; Rothenhäusler, B. Process and scaling ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188